Circular RNA ITCH: An Emerging Multifunctional Regulator
In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerou...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/3/359 |
| _version_ | 1797472666709393408 |
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| author | Kaixin Su Qiao Yi Xiaohan Dai Ousheng Liu |
| author_facet | Kaixin Su Qiao Yi Xiaohan Dai Ousheng Liu |
| author_sort | Kaixin Su |
| collection | DOAJ |
| description | In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerous cancers, and recently it was found to play an important role in bone diseases, diabetes mellitus, and cardiovascular diseases. However, the functions of circ-ITCH have not been completely understood. In this review, we comprehensively provide a conceptual framework to elucidate circ-ITCH biological functions of cell proliferation, apoptosis and differentiation, and the pathological mechanisms of inflammation, drug resistance/toxicity, and tumorigenesis. Finally, we summarize its clinical applications in various diseases. This research aimed at clarifying the role of circ-ITCH, which could be a promising therapeutic target. |
| first_indexed | 2024-03-09T20:04:35Z |
| format | Article |
| id | doaj.art-266b1822ce514680abb7c87a266844f8 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:04:35Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-266b1822ce514680abb7c87a266844f82023-11-24T00:34:47ZengMDPI AGBiomolecules2218-273X2022-02-0112335910.3390/biom12030359Circular RNA ITCH: An Emerging Multifunctional RegulatorKaixin Su0Qiao Yi1Xiaohan Dai2Ousheng Liu3Academician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha 410008, ChinaAcademician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha 410008, ChinaAcademician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha 410008, ChinaAcademician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha 410008, ChinaIn the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerous cancers, and recently it was found to play an important role in bone diseases, diabetes mellitus, and cardiovascular diseases. However, the functions of circ-ITCH have not been completely understood. In this review, we comprehensively provide a conceptual framework to elucidate circ-ITCH biological functions of cell proliferation, apoptosis and differentiation, and the pathological mechanisms of inflammation, drug resistance/toxicity, and tumorigenesis. Finally, we summarize its clinical applications in various diseases. This research aimed at clarifying the role of circ-ITCH, which could be a promising therapeutic target.https://www.mdpi.com/2218-273X/12/3/359circular RNAscirc-ITCHITCHbiological functionspathological mechanisms |
| spellingShingle | Kaixin Su Qiao Yi Xiaohan Dai Ousheng Liu Circular RNA ITCH: An Emerging Multifunctional Regulator Biomolecules circular RNAs circ-ITCH ITCH biological functions pathological mechanisms |
| title | Circular RNA ITCH: An Emerging Multifunctional Regulator |
| title_full | Circular RNA ITCH: An Emerging Multifunctional Regulator |
| title_fullStr | Circular RNA ITCH: An Emerging Multifunctional Regulator |
| title_full_unstemmed | Circular RNA ITCH: An Emerging Multifunctional Regulator |
| title_short | Circular RNA ITCH: An Emerging Multifunctional Regulator |
| title_sort | circular rna itch an emerging multifunctional regulator |
| topic | circular RNAs circ-ITCH ITCH biological functions pathological mechanisms |
| url | https://www.mdpi.com/2218-273X/12/3/359 |
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