Interorganelle Communication between Mitochondria and the Endolysosomal System
The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcell.2017.00095/full |
| _version_ | 1818141623390830592 |
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| author | Gonzalo Soto-Heredero Francesc Baixauli María Mittelbrunn María Mittelbrunn |
| author_facet | Gonzalo Soto-Heredero Francesc Baixauli María Mittelbrunn María Mittelbrunn |
| author_sort | Gonzalo Soto-Heredero |
| collection | DOAJ |
| description | The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation. Here, we present what is currently known about the functional and physical communication between mitochondria and lysosomes or lysosome-related organelles, and their role in sustaining cellular homeostasis. |
| first_indexed | 2024-12-11T11:02:49Z |
| format | Article |
| id | doaj.art-266bb080bd6f459c8d296c2847b450ab |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-11T11:02:49Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-266bb080bd6f459c8d296c2847b450ab2022-12-22T01:09:48ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2017-11-01510.3389/fcell.2017.00095314013Interorganelle Communication between Mitochondria and the Endolysosomal SystemGonzalo Soto-Heredero0Francesc Baixauli1María Mittelbrunn2María Mittelbrunn3Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, SpainMax Planck Institute of Immunobiology and Epigenetics, Freiburg, GermanyCentro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, SpainInstituto de Investigación Hospital 12 de Octubre, Madrid, SpainThe function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation. Here, we present what is currently known about the functional and physical communication between mitochondria and lysosomes or lysosome-related organelles, and their role in sustaining cellular homeostasis.http://journal.frontiersin.org/article/10.3389/fcell.2017.00095/fulllysosomeexosomesautophagyquality controlproteostasisaging |
| spellingShingle | Gonzalo Soto-Heredero Francesc Baixauli María Mittelbrunn María Mittelbrunn Interorganelle Communication between Mitochondria and the Endolysosomal System Frontiers in Cell and Developmental Biology lysosome exosomes autophagy quality control proteostasis aging |
| title | Interorganelle Communication between Mitochondria and the Endolysosomal System |
| title_full | Interorganelle Communication between Mitochondria and the Endolysosomal System |
| title_fullStr | Interorganelle Communication between Mitochondria and the Endolysosomal System |
| title_full_unstemmed | Interorganelle Communication between Mitochondria and the Endolysosomal System |
| title_short | Interorganelle Communication between Mitochondria and the Endolysosomal System |
| title_sort | interorganelle communication between mitochondria and the endolysosomal system |
| topic | lysosome exosomes autophagy quality control proteostasis aging |
| url | http://journal.frontiersin.org/article/10.3389/fcell.2017.00095/full |
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