Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial
Abstract Background We conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vaccinated), to determine the prevalence and risk factors for Staphylococc...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-08-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2685-1 |
| _version_ | 1819038083496017920 |
|---|---|
| author | Abdoulie Bojang Lindsay Kendall Effua Usuf Uzochukwu Egere Sarah Mulwa Martin Antonio Brian Greenwood Philip C. Hill Anna Roca |
| author_facet | Abdoulie Bojang Lindsay Kendall Effua Usuf Uzochukwu Egere Sarah Mulwa Martin Antonio Brian Greenwood Philip C. Hill Anna Roca |
| author_sort | Abdoulie Bojang |
| collection | DOAJ |
| description | Abstract Background We conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vaccinated), to determine the prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage. Methods Two hundred thirty-two children aged 5–10 years were recruited and followed from 4 to 20 months after vaccination started. We collected 1264 nasopharyngeal swabs (NPS). S. aureus was isolated following conventional microbiological methods. Risk factors for carriage were assessed by logistic regression. Results Prevalence of S. aureus carriage was 25.9%. In the univariable analysis, prevalence of S. aureus carriage was higher among children living in villages wholly-vaccinated with PCV-7 [OR = 1.57 95%CI (1.14 to 2.15)] and children with least 1 year of education [OR = 1.44 95%CI (1.07 to 1.92)]. S. aureus carriage was also higher during the rainy season [OR = 1.59 95%CI (1.20 to 2.11)]. Carriage of S. pneumoniae did not have any effect on S. aureus carriage for any pneumococcal, vaccine-type (VT) or non-vaccine-type (NVT) carriage. Multivariate analysis showed that the higher prevalence of S. aureus observed among children living in villages wholly-vaccinated with PCV-7 occurred only during the rainy season OR 2.72 95%CI (1.61–4.60) and not in the dry season OR 1.28 95%CI (0.78–2.09). Conclusions Prevalence of nasopharyngeal carriage of S. aureus among Gambian children increased during the rainy season among those children living in PCV-7 wholly vaccinated communities. However, carriage of S. aureus is not associated with carriage of S. pneumoniae. Trial registration ISRCTN51695599 . Registered August 04th 2006. |
| first_indexed | 2024-12-21T08:31:40Z |
| format | Article |
| id | doaj.art-266bd4f4e7da4df3a7cb6d4197882fb9 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-21T08:31:40Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-266bd4f4e7da4df3a7cb6d4197882fb92022-12-21T19:10:11ZengBMCBMC Infectious Diseases1471-23342017-08-011711810.1186/s12879-017-2685-1Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trialAbdoulie Bojang0Lindsay Kendall1Effua Usuf2Uzochukwu Egere3Sarah Mulwa4Martin Antonio5Brian Greenwood6Philip C. Hill7Anna Roca8Medical Research Council UnitMedical Research Council UnitMedical Research Council UnitMedical Research Council UnitMedical Research Council UnitMedical Research Council UnitFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical MedicineMedical Research Council UnitMedical Research Council UnitAbstract Background We conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vaccinated), to determine the prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage. Methods Two hundred thirty-two children aged 5–10 years were recruited and followed from 4 to 20 months after vaccination started. We collected 1264 nasopharyngeal swabs (NPS). S. aureus was isolated following conventional microbiological methods. Risk factors for carriage were assessed by logistic regression. Results Prevalence of S. aureus carriage was 25.9%. In the univariable analysis, prevalence of S. aureus carriage was higher among children living in villages wholly-vaccinated with PCV-7 [OR = 1.57 95%CI (1.14 to 2.15)] and children with least 1 year of education [OR = 1.44 95%CI (1.07 to 1.92)]. S. aureus carriage was also higher during the rainy season [OR = 1.59 95%CI (1.20 to 2.11)]. Carriage of S. pneumoniae did not have any effect on S. aureus carriage for any pneumococcal, vaccine-type (VT) or non-vaccine-type (NVT) carriage. Multivariate analysis showed that the higher prevalence of S. aureus observed among children living in villages wholly-vaccinated with PCV-7 occurred only during the rainy season OR 2.72 95%CI (1.61–4.60) and not in the dry season OR 1.28 95%CI (0.78–2.09). Conclusions Prevalence of nasopharyngeal carriage of S. aureus among Gambian children increased during the rainy season among those children living in PCV-7 wholly vaccinated communities. However, carriage of S. aureus is not associated with carriage of S. pneumoniae. Trial registration ISRCTN51695599 . Registered August 04th 2006.http://link.springer.com/article/10.1186/s12879-017-2685-1S. aureusPCVNasopharyngeal carriageSeasonalityRisk factorThe Gambia |
| spellingShingle | Abdoulie Bojang Lindsay Kendall Effua Usuf Uzochukwu Egere Sarah Mulwa Martin Antonio Brian Greenwood Philip C. Hill Anna Roca Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial BMC Infectious Diseases S. aureus PCV Nasopharyngeal carriage Seasonality Risk factor The Gambia |
| title | Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial |
| title_full | Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial |
| title_fullStr | Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial |
| title_full_unstemmed | Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial |
| title_short | Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial |
| title_sort | prevalence and risk factors for staphylococcus aureus nasopharyngeal carriage during a pcv trial |
| topic | S. aureus PCV Nasopharyngeal carriage Seasonality Risk factor The Gambia |
| url | http://link.springer.com/article/10.1186/s12879-017-2685-1 |
| work_keys_str_mv | AT abdouliebojang prevalenceandriskfactorsforstaphylococcusaureusnasopharyngealcarriageduringapcvtrial AT lindsaykendall prevalenceandriskfactorsforstaphylococcusaureusnasopharyngealcarriageduringapcvtrial AT effuausuf prevalenceandriskfactorsforstaphylococcusaureusnasopharyngealcarriageduringapcvtrial AT uzochukwuegere prevalenceandriskfactorsforstaphylococcusaureusnasopharyngealcarriageduringapcvtrial AT sarahmulwa prevalenceandriskfactorsforstaphylococcusaureusnasopharyngealcarriageduringapcvtrial AT martinantonio prevalenceandriskfactorsforstaphylococcusaureusnasopharyngealcarriageduringapcvtrial AT briangreenwood prevalenceandriskfactorsforstaphylococcusaureusnasopharyngealcarriageduringapcvtrial AT philipchill prevalenceandriskfactorsforstaphylococcusaureusnasopharyngealcarriageduringapcvtrial AT annaroca prevalenceandriskfactorsforstaphylococcusaureusnasopharyngealcarriageduringapcvtrial |