Impacts of quantum dots in molecular detection and bioimaging of cancer
Introduction: A number of assays have so far been exploited for detection of cancer biomarkers in various malignancies. However, the expression of cancer biomarker(s) appears to be extremely low, therefore accurate detection demands sensitive optical imaging probes. While optical detection using con...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2014-09-01
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| Series: | BioImpacts |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/BI/PDF/BI-4-149.pdf |
| _version_ | 1818131697612357632 |
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| author | Omid Mashinchian Mohammad Johari-Ahar Behnaz Ghaemi Mohammad Rashidi Jaleh Barar Yadollah Omidi |
| author_facet | Omid Mashinchian Mohammad Johari-Ahar Behnaz Ghaemi Mohammad Rashidi Jaleh Barar Yadollah Omidi |
| author_sort | Omid Mashinchian |
| collection | DOAJ |
| description | Introduction: A number of assays have so far
been exploited for detection of cancer biomarkers in various
malignancies. However, the expression of cancer biomarker(s) appears to
be extremely low, therefore accurate detection demands sensitive optical
imaging probes. While optical detection using conventional fluorophores
often fail due to photobleaching problems, quantum dots (QDs) offer
stable optical imaging in vitro and in vivo.
Methods: In this review, we
briefly overview the impacts of QDs in biology and its applications in
bioimaging of malignancies. We will also delineate the existing
obstacles for early detection of cancer and the intensifying use of QDs
in advancement of diagnostic devices.
Results: Of the QDs, unlike the
II-VI type QDs (e.g., cadmium (Cd), selenium (Se) or tellurium (Te))
that possess inherent cytotoxicity, the I-III-VI 2 type QDs (e.g.,
AgInS2, CuInS2, ZnS-AgInS2) appear to be less toxic bioimaging agents
with better control of band-gap energies. As highly-sensitive bioimaging
probes, advanced hybrid QDs (e.g., QD-QD, fluorochrome-QD conjugates
used for sensing through fluorescence resonance energy transfer (FRET),
quenching, and barcoding techniques) have also been harnessed for the
detection of biomarkers and the monitoring of delivery of drugs/genes to
the target sites. Antibody-QD (Ab-QD) and aptamer-QD (Ap-QD)
bioconjugates, once target the relevant biomarker, can provide highly
stable photoluminescence (PL) at the target sites. In addition to their
potential as nanobiosensors, the bioconjugates of QDs with homing
devices have successfully been used for the development of smart
nanosystems (NSs) providing targeted bioimaging and photodynamic therapy
(PDT).
Conclusion: Having possessed great
deal of photonic characteristics, QDs can be used for development of
seamless multifunctional nanomedicines, theranostics and nanobiosensors. |
| first_indexed | 2024-12-11T08:25:03Z |
| format | Article |
| id | doaj.art-26700170b2fb419aafd45f3814bd148f |
| institution | Directory Open Access Journal |
| issn | 2228-5652 2228-5660 |
| language | English |
| last_indexed | 2024-12-11T08:25:03Z |
| publishDate | 2014-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | BioImpacts |
| spelling | doaj.art-26700170b2fb419aafd45f3814bd148f2022-12-22T01:14:34ZengTabriz University of Medical SciencesBioImpacts2228-56522228-56602014-09-014314916610.15171/bi.2014.008BI_64_20150822090708Impacts of quantum dots in molecular detection and bioimaging of cancerOmid Mashinchian0Mohammad Johari-Ahar1Behnaz Ghaemi2Mohammad Rashidi3Jaleh Barar4Yadollah Omidi5Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranResearch Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, IranResearch Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranResearch Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranResearch Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranIntroduction: A number of assays have so far been exploited for detection of cancer biomarkers in various malignancies. However, the expression of cancer biomarker(s) appears to be extremely low, therefore accurate detection demands sensitive optical imaging probes. While optical detection using conventional fluorophores often fail due to photobleaching problems, quantum dots (QDs) offer stable optical imaging in vitro and in vivo. Methods: In this review, we briefly overview the impacts of QDs in biology and its applications in bioimaging of malignancies. We will also delineate the existing obstacles for early detection of cancer and the intensifying use of QDs in advancement of diagnostic devices. Results: Of the QDs, unlike the II-VI type QDs (e.g., cadmium (Cd), selenium (Se) or tellurium (Te)) that possess inherent cytotoxicity, the I-III-VI 2 type QDs (e.g., AgInS2, CuInS2, ZnS-AgInS2) appear to be less toxic bioimaging agents with better control of band-gap energies. As highly-sensitive bioimaging probes, advanced hybrid QDs (e.g., QD-QD, fluorochrome-QD conjugates used for sensing through fluorescence resonance energy transfer (FRET), quenching, and barcoding techniques) have also been harnessed for the detection of biomarkers and the monitoring of delivery of drugs/genes to the target sites. Antibody-QD (Ab-QD) and aptamer-QD (Ap-QD) bioconjugates, once target the relevant biomarker, can provide highly stable photoluminescence (PL) at the target sites. In addition to their potential as nanobiosensors, the bioconjugates of QDs with homing devices have successfully been used for the development of smart nanosystems (NSs) providing targeted bioimaging and photodynamic therapy (PDT). Conclusion: Having possessed great deal of photonic characteristics, QDs can be used for development of seamless multifunctional nanomedicines, theranostics and nanobiosensors.http://journals.tbzmed.ac.ir/BI/PDF/BI-4-149.pdfBioimagingBioconjugatesCancerMultimodal nanomedicinesQuantum dotsTheranostics |
| spellingShingle | Omid Mashinchian Mohammad Johari-Ahar Behnaz Ghaemi Mohammad Rashidi Jaleh Barar Yadollah Omidi Impacts of quantum dots in molecular detection and bioimaging of cancer BioImpacts Bioimaging Bioconjugates Cancer Multimodal nanomedicines Quantum dots Theranostics |
| title | Impacts of quantum dots in molecular detection and bioimaging of cancer |
| title_full | Impacts of quantum dots in molecular detection and bioimaging of cancer |
| title_fullStr | Impacts of quantum dots in molecular detection and bioimaging of cancer |
| title_full_unstemmed | Impacts of quantum dots in molecular detection and bioimaging of cancer |
| title_short | Impacts of quantum dots in molecular detection and bioimaging of cancer |
| title_sort | impacts of quantum dots in molecular detection and bioimaging of cancer |
| topic | Bioimaging Bioconjugates Cancer Multimodal nanomedicines Quantum dots Theranostics |
| url | http://journals.tbzmed.ac.ir/BI/PDF/BI-4-149.pdf |
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