Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis
<p>Abstract</p> <p>Background</p> <p>It is well known that pulmonary alveolar proteinosis(PAP) is characterised by accumulation of surfactant lipids and proteins within airspaces. However, few previous data describe the serum lipid levels associated with PAP.</p>...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-01-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://www.lipidworld.com/content/11/1/12 |
| _version_ | 1818915467020992512 |
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| author | Fang Cun S Wang Ying C Zhang Tao H Wu Jing Wang Wei Wang Chun Zhang Ming Y |
| author_facet | Fang Cun S Wang Ying C Zhang Tao H Wu Jing Wang Wei Wang Chun Zhang Ming Y |
| author_sort | Fang Cun S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>It is well known that pulmonary alveolar proteinosis(PAP) is characterised by accumulation of surfactant lipids and proteins within airspaces. However, few previous data describe the serum lipid levels associated with PAP.</p> <p>Materials and methods</p> <p>We retrospectively reviewed 25 patients with idiopathic PAP(iPAP). The serum lipid levels of patients with idiopathic PAP were compared with those of the healthy volunteers. In patients and healthy subjects, the LDL-C/HDL-C ratios were 2.94 ± 1.21 and 1.60 ± 0.70, respectively (<it>p </it>< 0.001), HDL-C were 1.11 ± 0.27 and 1.71 ± 0.71 respectively (<it>p </it>< 0.001). The values of LDL-C correlated significantly with those of PaO2 and P<sub>A-a</sub>O2 (r = -0.685, <it>p </it>= 0.003, and r = 0.688, <it>p </it>= 0.003, respectively). The values of LDL-C/HDL-C ratios also correlated with PaO2 levels and PA-aO2 levels (r = -0.698, p = 0.003, and r = 0.653, p = 0.006, respectively). 11 and 13 patients experienced respectively a decline in TC and LDL-C levels following whole lung lavage(WLL), the median decline was 0.71 mmol/L(<it>p </it>< 0.009) and 0.47 mmol/L(<it>p </it>< 0.003), respectively.</p> <p>Conclusions</p> <p>the serum lipid levels, especially the levels of LDL-C and LDL-C/HDL-C, may reflect the severity of the disease in PAP patients, and predict the therapeutic effect of WLL.</p> |
| first_indexed | 2024-12-20T00:02:44Z |
| format | Article |
| id | doaj.art-2671535e296842e88e86a046fca56f95 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-20T00:02:44Z |
| publishDate | 2012-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-2671535e296842e88e86a046fca56f952022-12-21T20:00:45ZengBMCLipids in Health and Disease1476-511X2012-01-011111210.1186/1476-511X-11-12Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosisFang Cun SWang Ying CZhang Tao HWu JingWang WeiWang ChunZhang Ming Y<p>Abstract</p> <p>Background</p> <p>It is well known that pulmonary alveolar proteinosis(PAP) is characterised by accumulation of surfactant lipids and proteins within airspaces. However, few previous data describe the serum lipid levels associated with PAP.</p> <p>Materials and methods</p> <p>We retrospectively reviewed 25 patients with idiopathic PAP(iPAP). The serum lipid levels of patients with idiopathic PAP were compared with those of the healthy volunteers. In patients and healthy subjects, the LDL-C/HDL-C ratios were 2.94 ± 1.21 and 1.60 ± 0.70, respectively (<it>p </it>< 0.001), HDL-C were 1.11 ± 0.27 and 1.71 ± 0.71 respectively (<it>p </it>< 0.001). The values of LDL-C correlated significantly with those of PaO2 and P<sub>A-a</sub>O2 (r = -0.685, <it>p </it>= 0.003, and r = 0.688, <it>p </it>= 0.003, respectively). The values of LDL-C/HDL-C ratios also correlated with PaO2 levels and PA-aO2 levels (r = -0.698, p = 0.003, and r = 0.653, p = 0.006, respectively). 11 and 13 patients experienced respectively a decline in TC and LDL-C levels following whole lung lavage(WLL), the median decline was 0.71 mmol/L(<it>p </it>< 0.009) and 0.47 mmol/L(<it>p </it>< 0.003), respectively.</p> <p>Conclusions</p> <p>the serum lipid levels, especially the levels of LDL-C and LDL-C/HDL-C, may reflect the severity of the disease in PAP patients, and predict the therapeutic effect of WLL.</p>http://www.lipidworld.com/content/11/1/12pulmonary alveolar proteinosishigh-density lipoprotein cholesterol lipidlow-density lipoprotein cholesterolwhole lung lavage |
| spellingShingle | Fang Cun S Wang Ying C Zhang Tao H Wu Jing Wang Wei Wang Chun Zhang Ming Y Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis Lipids in Health and Disease pulmonary alveolar proteinosis high-density lipoprotein cholesterol lipid low-density lipoprotein cholesterol whole lung lavage |
| title | Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis |
| title_full | Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis |
| title_fullStr | Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis |
| title_full_unstemmed | Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis |
| title_short | Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis |
| title_sort | clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis |
| topic | pulmonary alveolar proteinosis high-density lipoprotein cholesterol lipid low-density lipoprotein cholesterol whole lung lavage |
| url | http://www.lipidworld.com/content/11/1/12 |
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