Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020)
Metal-mediated cyclizations are important transformations in a natural product total synthesis. The Pauson-Khand reaction, particularly powerful for establishing cyclopentenone-containing structures, is distinguished as one of the most attractive annulation processes routinely employed in synthesis...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Catalysts |
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| Online Access: | https://www.mdpi.com/2073-4344/10/10/1199 |
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| author | Sijia Chen Chongguo Jiang Nan Zheng Zhen Yang Lili Shi |
| author_facet | Sijia Chen Chongguo Jiang Nan Zheng Zhen Yang Lili Shi |
| author_sort | Sijia Chen |
| collection | DOAJ |
| description | Metal-mediated cyclizations are important transformations in a natural product total synthesis. The Pauson-Khand reaction, particularly powerful for establishing cyclopentenone-containing structures, is distinguished as one of the most attractive annulation processes routinely employed in synthesis campaigns. This review covers Co, Rh, and Pd catalyzed Pauson-Khand reaction and summarizes its strategic applications in total syntheses of structurally complex natural products in the last five years. Additionally, the hetero-Pauson-Khand reaction in the synthesis of heterocycles will also be discussed. Focusing on the panorama of organic synthesis, this review highlights the strategically developed Pauson-Khand reaction in fulfilling total synthetic tasks and its synthetic attractiveness is aimed to be illustrated. |
| first_indexed | 2024-03-10T15:34:16Z |
| format | Article |
| id | doaj.art-26729ae73c2446c4822f274cc71e7547 |
| institution | Directory Open Access Journal |
| issn | 2073-4344 |
| language | English |
| last_indexed | 2024-03-10T15:34:16Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Catalysts |
| spelling | doaj.art-26729ae73c2446c4822f274cc71e75472023-11-20T17:22:58ZengMDPI AGCatalysts2073-43442020-10-011010119910.3390/catal10101199Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020)Sijia Chen0Chongguo Jiang1Nan Zheng2Zhen Yang3Lili Shi4State Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaState Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaState Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaState Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaState Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaMetal-mediated cyclizations are important transformations in a natural product total synthesis. The Pauson-Khand reaction, particularly powerful for establishing cyclopentenone-containing structures, is distinguished as one of the most attractive annulation processes routinely employed in synthesis campaigns. This review covers Co, Rh, and Pd catalyzed Pauson-Khand reaction and summarizes its strategic applications in total syntheses of structurally complex natural products in the last five years. Additionally, the hetero-Pauson-Khand reaction in the synthesis of heterocycles will also be discussed. Focusing on the panorama of organic synthesis, this review highlights the strategically developed Pauson-Khand reaction in fulfilling total synthetic tasks and its synthetic attractiveness is aimed to be illustrated.https://www.mdpi.com/2073-4344/10/10/1199metal-mediated reactionsPauson-Khand reactioncyclopentenonesnatural products total syntheses |
| spellingShingle | Sijia Chen Chongguo Jiang Nan Zheng Zhen Yang Lili Shi Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020) Catalysts metal-mediated reactions Pauson-Khand reaction cyclopentenones natural products total syntheses |
| title | Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020) |
| title_full | Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020) |
| title_fullStr | Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020) |
| title_full_unstemmed | Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020) |
| title_short | Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020) |
| title_sort | evolution of pauson khand reaction strategic applications in total syntheses of architecturally complex natural products 2016 2020 |
| topic | metal-mediated reactions Pauson-Khand reaction cyclopentenones natural products total syntheses |
| url | https://www.mdpi.com/2073-4344/10/10/1199 |
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