Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study
BackgroundMicrocirculation plays a vital role in scleroderma physiopathology and the mechanism of fat survival.ObjectiveThis study aims to assess the blood perfusion change after fat grafting and evaluate the relationship between blood perfusion and fat graft retention in patients with localized scl...
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| Format: | Article |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.945691/full |
| _version_ | 1818550057187672064 |
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| author | Hayson Chenyu Wang Yunzhu Li Zhujun Li Liquan Wang Ziming Li Xiao Long |
| author_facet | Hayson Chenyu Wang Yunzhu Li Zhujun Li Liquan Wang Ziming Li Xiao Long |
| author_sort | Hayson Chenyu Wang |
| collection | DOAJ |
| description | BackgroundMicrocirculation plays a vital role in scleroderma physiopathology and the mechanism of fat survival.ObjectiveThis study aims to assess the blood perfusion change after fat grafting and evaluate the relationship between blood perfusion and fat graft retention in patients with localized scleroderma (LS).MethodsA pilot study was conducted in patients with LS receiving autologous fat grafting (AFG). Fat graft retention measured by magnetic resonance imaging (MRI) analysis and blood flow perfusion measured by laser speckle contrast imaging 6 months postoperatively were noted. PUMC Localized Scleroderma Facial Aesthetic Index was used to assess the improvement of facial aesthetic impairment.ResultsThe fat retention at the 6-month follow-up was 34.56 ± 11.89 percent. At the 6th month of follow-up, the relative blood perfusion at the lesion area was 115.08 ± 14.39 PU, significantly higher than 100.42 ± 10.62 PU at the pre-operation (p = 0.010). The blood perfusion at follow-up increased by an average of 1.15 ± 0.14 times before the operation. No association between the increase in the blood flow perfusions and fat graft retention was found (r = −0.082, p = 0.811).ConclusionLocal blood perfusion in the lesion area relatively increased after AFG, but no direct relationship was found between fat retention and increased blood supply. |
| first_indexed | 2024-12-12T08:41:22Z |
| format | Article |
| id | doaj.art-26729eb44ae0413e80a924cdbb5ae2a5 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T08:41:22Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-26729eb44ae0413e80a924cdbb5ae2a52022-12-22T00:30:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-06-01910.3389/fmed.2022.945691945691Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot StudyHayson Chenyu Wang0Yunzhu Li1Zhujun Li2Liquan Wang3Ziming Li4Xiao Long5Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaBackgroundMicrocirculation plays a vital role in scleroderma physiopathology and the mechanism of fat survival.ObjectiveThis study aims to assess the blood perfusion change after fat grafting and evaluate the relationship between blood perfusion and fat graft retention in patients with localized scleroderma (LS).MethodsA pilot study was conducted in patients with LS receiving autologous fat grafting (AFG). Fat graft retention measured by magnetic resonance imaging (MRI) analysis and blood flow perfusion measured by laser speckle contrast imaging 6 months postoperatively were noted. PUMC Localized Scleroderma Facial Aesthetic Index was used to assess the improvement of facial aesthetic impairment.ResultsThe fat retention at the 6-month follow-up was 34.56 ± 11.89 percent. At the 6th month of follow-up, the relative blood perfusion at the lesion area was 115.08 ± 14.39 PU, significantly higher than 100.42 ± 10.62 PU at the pre-operation (p = 0.010). The blood perfusion at follow-up increased by an average of 1.15 ± 0.14 times before the operation. No association between the increase in the blood flow perfusions and fat graft retention was found (r = −0.082, p = 0.811).ConclusionLocal blood perfusion in the lesion area relatively increased after AFG, but no direct relationship was found between fat retention and increased blood supply.https://www.frontiersin.org/articles/10.3389/fmed.2022.945691/fulllocalized sclerodermaautologous fat graftingmicrocirculationblood flowfat retention |
| spellingShingle | Hayson Chenyu Wang Yunzhu Li Zhujun Li Liquan Wang Ziming Li Xiao Long Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study Frontiers in Medicine localized scleroderma autologous fat grafting microcirculation blood flow fat retention |
| title | Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study |
| title_full | Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study |
| title_fullStr | Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study |
| title_full_unstemmed | Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study |
| title_short | Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study |
| title_sort | association between fat graft retention and blood flow in localized scleroderma patients a pilot study |
| topic | localized scleroderma autologous fat grafting microcirculation blood flow fat retention |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.945691/full |
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