Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length
Abstract Observational studies suggest certain sleep traits are associated with telomere length, but the causal nature of these associations is unclear. The study aimed to determine the causal associations between 11 sleep-related traits and leukocyte telomere length (LTL) through two-sample Mendeli...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05397-7 |
| _version_ | 1827708942496563200 |
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| author | Jingyi Hu Jiawen Lu Qiuhan Lu Weipin Weng Zixuan Guan Zhenqian Wang |
| author_facet | Jingyi Hu Jiawen Lu Qiuhan Lu Weipin Weng Zixuan Guan Zhenqian Wang |
| author_sort | Jingyi Hu |
| collection | DOAJ |
| description | Abstract Observational studies suggest certain sleep traits are associated with telomere length, but the causal nature of these associations is unclear. The study aimed to determine the causal associations between 11 sleep-related traits and leukocyte telomere length (LTL) through two-sample Mendelian randomization and colocalization analyses using the summary statistics from large-scale genome-wide association studies. Univariable Mendelian randomization indicates that genetically determined short sleep is associated with decreased LTL, while morning chronotype is associated with increased LTL. Multivariable Mendelian randomization further supports the findings and colocalization analysis identifies shared common genetic variants for these two associations. No genetic evidence is observed for associations between other sleep-related traits and LTL. Sensitivity MR methods, reverse MR and re-running MR after removing potential pleiotropic genetic variants enhance the robustness of the results. These findings indicate that prioritizing morning chronotype and avoiding short sleep is beneficial for attenuating telomere attrition. Consequently, addressing sleep duration and chronotype could serve as practical intervention strategies. |
| first_indexed | 2024-03-10T17:12:55Z |
| format | Article |
| id | doaj.art-267312c5182949c582ed5476e4b09fb6 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-10T17:12:55Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-267312c5182949c582ed5476e4b09fb62023-11-20T10:34:58ZengNature PortfolioCommunications Biology2399-36422023-10-016111110.1038/s42003-023-05397-7Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere lengthJingyi Hu0Jiawen Lu1Qiuhan Lu2Weipin Weng3Zixuan Guan4Zhenqian Wang5National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South UniversitySchool of Public Health (Shenzhen), Sun Yat-sen UniversitySchool of Public Health (Shenzhen), Sun Yat-sen UniversityDepartment of Neurology, Center for Cognitive Neurology, Fujian Medical University Union HospitalChongchuan District Center for Disease Control and PreventionSchool of Public Health (Shenzhen), Sun Yat-sen UniversityAbstract Observational studies suggest certain sleep traits are associated with telomere length, but the causal nature of these associations is unclear. The study aimed to determine the causal associations between 11 sleep-related traits and leukocyte telomere length (LTL) through two-sample Mendelian randomization and colocalization analyses using the summary statistics from large-scale genome-wide association studies. Univariable Mendelian randomization indicates that genetically determined short sleep is associated with decreased LTL, while morning chronotype is associated with increased LTL. Multivariable Mendelian randomization further supports the findings and colocalization analysis identifies shared common genetic variants for these two associations. No genetic evidence is observed for associations between other sleep-related traits and LTL. Sensitivity MR methods, reverse MR and re-running MR after removing potential pleiotropic genetic variants enhance the robustness of the results. These findings indicate that prioritizing morning chronotype and avoiding short sleep is beneficial for attenuating telomere attrition. Consequently, addressing sleep duration and chronotype could serve as practical intervention strategies.https://doi.org/10.1038/s42003-023-05397-7 |
| spellingShingle | Jingyi Hu Jiawen Lu Qiuhan Lu Weipin Weng Zixuan Guan Zhenqian Wang Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length Communications Biology |
| title | Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length |
| title_full | Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length |
| title_fullStr | Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length |
| title_full_unstemmed | Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length |
| title_short | Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length |
| title_sort | mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length |
| url | https://doi.org/10.1038/s42003-023-05397-7 |
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