Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial
Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is associated with an acute inflammatory response and melatonin has a variety of immunomodulatory and antioxidant effects studied experimentally in pancreatobiliary pathology. Aims: The aim of our study was to evaluate the effects o...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-07-01
|
| Series: | Revista de Gastroenterología de México (English Edition) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255534X16300329 |
| _version_ | 1818525612819611648 |
|---|---|
| author | B. Hernández-Velázquez C.R. Camara-Lemarroy J.A. González-González D. García-Compean R. Monreal-Robles P. Cordero-Pérez L.E. Muñoz-Espinosa |
| author_facet | B. Hernández-Velázquez C.R. Camara-Lemarroy J.A. González-González D. García-Compean R. Monreal-Robles P. Cordero-Pérez L.E. Muñoz-Espinosa |
| author_sort | B. Hernández-Velázquez |
| collection | DOAJ |
| description | Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is associated with an acute inflammatory response and melatonin has a variety of immunomodulatory and antioxidant effects studied experimentally in pancreatobiliary pathology.
Aims: The aim of our study was to evaluate the effects of peri-procedural administration of melatonin on the inflammatory response and lipid peroxidation associated with ERCP.
Methods: In this proof-of-concept clinical trial, 37 patients with a high probability of choledocholithiasis were randomized to receive peri-procedure (ERCP) melatonin or placebo. We measured the serum concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), lipid peroxidation, amylase, and liver function tests 24 h before and after the procedure.
Results: We found no pre-procedure or post-procedure differences between the melatonin group or the placebo group (P>.05) in the serum concentrations of TNF-alpha (melatonin: 153.8 vs. 149.4 ng/m; placebo: 103.5 vs. 107.3 ng/ml), IL-6 (melatonin: 131.8 vs. 133.3 ng/ml; placebo: 177.8 vs. 197.8 ng/ml), or VEGF (melatonin: 157.3 vs. 157.8 pg/ml; placebo: 97.3 vs. 97.8 pg/ml), or in relation to lipid peroxidation (melatonin: 39.2 vs. 72.3 μg/ml; placebo: 66.4 vs. 90.5 μg/ml). After ERCP, a significant decrease in the AST, ALT, and total bilirubin levels was found only in the melatonin group (P<.05). The administration of melatonin was safe and tolerable.
Conclusions: Melatonin is safe and tolerable in patients undergoing ERCP, but it does not appear to affect inflammatory cytokine concentrations or lipid peroxidation. |
| first_indexed | 2024-12-11T06:11:19Z |
| format | Article |
| id | doaj.art-2673913dc7c54265b1b2ec893f5fb0e8 |
| institution | Directory Open Access Journal |
| issn | 2255-534X |
| language | English |
| last_indexed | 2024-12-11T06:11:19Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista de Gastroenterología de México (English Edition) |
| spelling | doaj.art-2673913dc7c54265b1b2ec893f5fb0e82022-12-22T01:18:07ZengElsevierRevista de Gastroenterología de México (English Edition)2255-534X2016-07-0181314114810.1016/j.rgmxen.2016.06.014Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trialB. Hernández-Velázquez0C.R. Camara-Lemarroy1J.A. González-González2D. García-Compean3R. Monreal-Robles4P. Cordero-Pérez5L.E. Muñoz-Espinosa6Servicio de Gastroenterología y Endoscopia Digestiva, Hospital Universitario «Dr. José E. González», Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoDepartamento de Medicina Interna, Hospital Universitario «Dr. José E. González», Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoServicio de Gastroenterología y Endoscopia Digestiva, Hospital Universitario «Dr. José E. González», Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoServicio de Gastroenterología y Endoscopia Digestiva, Hospital Universitario «Dr. José E. González», Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoServicio de Gastroenterología y Endoscopia Digestiva, Hospital Universitario «Dr. José E. González», Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoUnidad de Hígado, Hospital Universitario «Dr. José E. González», Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoUnidad de Hígado, Hospital Universitario «Dr. José E. González», Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoIntroduction: Endoscopic retrograde cholangiopancreatography (ERCP) is associated with an acute inflammatory response and melatonin has a variety of immunomodulatory and antioxidant effects studied experimentally in pancreatobiliary pathology. Aims: The aim of our study was to evaluate the effects of peri-procedural administration of melatonin on the inflammatory response and lipid peroxidation associated with ERCP. Methods: In this proof-of-concept clinical trial, 37 patients with a high probability of choledocholithiasis were randomized to receive peri-procedure (ERCP) melatonin or placebo. We measured the serum concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), lipid peroxidation, amylase, and liver function tests 24 h before and after the procedure. Results: We found no pre-procedure or post-procedure differences between the melatonin group or the placebo group (P>.05) in the serum concentrations of TNF-alpha (melatonin: 153.8 vs. 149.4 ng/m; placebo: 103.5 vs. 107.3 ng/ml), IL-6 (melatonin: 131.8 vs. 133.3 ng/ml; placebo: 177.8 vs. 197.8 ng/ml), or VEGF (melatonin: 157.3 vs. 157.8 pg/ml; placebo: 97.3 vs. 97.8 pg/ml), or in relation to lipid peroxidation (melatonin: 39.2 vs. 72.3 μg/ml; placebo: 66.4 vs. 90.5 μg/ml). After ERCP, a significant decrease in the AST, ALT, and total bilirubin levels was found only in the melatonin group (P<.05). The administration of melatonin was safe and tolerable. Conclusions: Melatonin is safe and tolerable in patients undergoing ERCP, but it does not appear to affect inflammatory cytokine concentrations or lipid peroxidation.http://www.sciencedirect.com/science/article/pii/S2255534X16300329Endoscopic retrograde cholangiopancreatographyMelatonin in humansTumor necrosis factor-alphaLipid peroxidation |
| spellingShingle | B. Hernández-Velázquez C.R. Camara-Lemarroy J.A. González-González D. García-Compean R. Monreal-Robles P. Cordero-Pérez L.E. Muñoz-Espinosa Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial Revista de Gastroenterología de México (English Edition) Endoscopic retrograde cholangiopancreatography Melatonin in humans Tumor necrosis factor-alpha Lipid peroxidation |
| title | Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial |
| title_full | Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial |
| title_fullStr | Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial |
| title_short | Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial |
| title_sort | effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography a randomized double blind placebo controlled trial |
| topic | Endoscopic retrograde cholangiopancreatography Melatonin in humans Tumor necrosis factor-alpha Lipid peroxidation |
| url | http://www.sciencedirect.com/science/article/pii/S2255534X16300329 |
| work_keys_str_mv | AT bhernandezvelazquez effectsofmelatoninontheacuteinflammatoryresponseassociatedwithendoscopicretrogradecholangiopancreatographyarandomizeddoubleblindplacebocontrolledtrial AT crcamaralemarroy effectsofmelatoninontheacuteinflammatoryresponseassociatedwithendoscopicretrogradecholangiopancreatographyarandomizeddoubleblindplacebocontrolledtrial AT jagonzalezgonzalez effectsofmelatoninontheacuteinflammatoryresponseassociatedwithendoscopicretrogradecholangiopancreatographyarandomizeddoubleblindplacebocontrolledtrial AT dgarciacompean effectsofmelatoninontheacuteinflammatoryresponseassociatedwithendoscopicretrogradecholangiopancreatographyarandomizeddoubleblindplacebocontrolledtrial AT rmonrealrobles effectsofmelatoninontheacuteinflammatoryresponseassociatedwithendoscopicretrogradecholangiopancreatographyarandomizeddoubleblindplacebocontrolledtrial AT pcorderoperez effectsofmelatoninontheacuteinflammatoryresponseassociatedwithendoscopicretrogradecholangiopancreatographyarandomizeddoubleblindplacebocontrolledtrial AT lemunozespinosa effectsofmelatoninontheacuteinflammatoryresponseassociatedwithendoscopicretrogradecholangiopancreatographyarandomizeddoubleblindplacebocontrolledtrial |