Whole‐genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migration
Abstract Hybridization is widespread in nature and is a valuable tool in domestic breeding. The DHB (DaHuaBai) pig in South China is the product of such a breeding strategy, resulting in increased body weight compared with other pigs in the surrounding area. We analyzed genomic data from 20 Chinese...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-03-01
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| Series: | Evolutionary Applications |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/eva.13366 |
| _version_ | 1818755545099665408 |
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| author | Yuzhan Wang Chunyuan Zhang Yebo Peng Xinyu Cai Xiaoxiang Hu Mirte Bosse Yiqiang Zhao |
| author_facet | Yuzhan Wang Chunyuan Zhang Yebo Peng Xinyu Cai Xiaoxiang Hu Mirte Bosse Yiqiang Zhao |
| author_sort | Yuzhan Wang |
| collection | DOAJ |
| description | Abstract Hybridization is widespread in nature and is a valuable tool in domestic breeding. The DHB (DaHuaBai) pig in South China is the product of such a breeding strategy, resulting in increased body weight compared with other pigs in the surrounding area. We analyzed genomic data from 20 Chinese pig breeds and investigated the genomic architecture after breed formation of DHB. The breed showed inconsistency in genotype and body weight phenotype, in line with selection after hybridization. By quantifying introgression with a haplotype‐based approach, we proposed a two‐step introgression from large‐sized pigs into small‐sized pigs to produce DHB, consistent with the human migration events in Chinese history. Combining with gene prioritization and allele frequency analysis, we identify candidate genes that showed selection after introgression and that may affect body weight, such as IGF1R, SRC, and PCM1. Our research provides an example of a hybrid formation of domestic breeds along with human migration patterns. |
| first_indexed | 2024-12-18T05:40:51Z |
| format | Article |
| id | doaj.art-2673c2b1eb6345fe8805c610ad1efa81 |
| institution | Directory Open Access Journal |
| issn | 1752-4571 |
| language | English |
| last_indexed | 2024-12-18T05:40:51Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Evolutionary Applications |
| spelling | doaj.art-2673c2b1eb6345fe8805c610ad1efa812022-12-21T21:19:11ZengWileyEvolutionary Applications1752-45712022-03-0115350151410.1111/eva.13366Whole‐genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migrationYuzhan Wang0Chunyuan Zhang1Yebo Peng2Xinyu Cai3Xiaoxiang Hu4Mirte Bosse5Yiqiang Zhao6State Key Laboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing ChinaState Key Laboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing ChinaState Key Laboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing ChinaState Key Laboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing ChinaState Key Laboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing ChinaAnimal Breeding and Genomics Centre Wageningen University Wageningen The NetherlandsState Key Laboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing ChinaAbstract Hybridization is widespread in nature and is a valuable tool in domestic breeding. The DHB (DaHuaBai) pig in South China is the product of such a breeding strategy, resulting in increased body weight compared with other pigs in the surrounding area. We analyzed genomic data from 20 Chinese pig breeds and investigated the genomic architecture after breed formation of DHB. The breed showed inconsistency in genotype and body weight phenotype, in line with selection after hybridization. By quantifying introgression with a haplotype‐based approach, we proposed a two‐step introgression from large‐sized pigs into small‐sized pigs to produce DHB, consistent with the human migration events in Chinese history. Combining with gene prioritization and allele frequency analysis, we identify candidate genes that showed selection after introgression and that may affect body weight, such as IGF1R, SRC, and PCM1. Our research provides an example of a hybrid formation of domestic breeds along with human migration patterns.https://doi.org/10.1111/eva.13366body weightDaHuaBai pighuman migrationhybridizationPCM1two‐step introgression |
| spellingShingle | Yuzhan Wang Chunyuan Zhang Yebo Peng Xinyu Cai Xiaoxiang Hu Mirte Bosse Yiqiang Zhao Whole‐genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migration Evolutionary Applications body weight DaHuaBai pig human migration hybridization PCM1 two‐step introgression |
| title | Whole‐genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migration |
| title_full | Whole‐genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migration |
| title_fullStr | Whole‐genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migration |
| title_full_unstemmed | Whole‐genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migration |
| title_short | Whole‐genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migration |
| title_sort | whole genome analysis reveals the hybrid formation of chinese indigenous dhb pig following human migration |
| topic | body weight DaHuaBai pig human migration hybridization PCM1 two‐step introgression |
| url | https://doi.org/10.1111/eva.13366 |
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