The occurrence and development of induced pluripotent stem cells
The ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc (OSKM), known as “Yamanaka factors,” can reprogram or stimulate the production of induced pluripotent stem cells (iPSCs). Although OSKM is still the gold standard, there are multiple ways to reprogram cells into iPSC...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1389558/full |
| _version_ | 1827278443950112768 |
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| author | Yi Chen Meng Li Yanqing Wu |
| author_facet | Yi Chen Meng Li Yanqing Wu |
| author_sort | Yi Chen |
| collection | DOAJ |
| description | The ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc (OSKM), known as “Yamanaka factors,” can reprogram or stimulate the production of induced pluripotent stem cells (iPSCs). Although OSKM is still the gold standard, there are multiple ways to reprogram cells into iPSCs. In recent years, significant progress has been made in improving the efficiency of this technology. Ten years after the first report was published, human pluripotent stem cells have gradually been applied in clinical settings, including disease modeling, cell therapy, new drug development, and cell derivation. Here, we provide a review of the discovery of iPSCs and their applications in disease and development. |
| first_indexed | 2024-04-24T07:57:57Z |
| format | Article |
| id | doaj.art-26795b29d6f24aadb427f4cbe3661090 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-24T07:57:57Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-26795b29d6f24aadb427f4cbe36610902024-04-18T04:24:22ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-04-011510.3389/fgene.2024.13895581389558The occurrence and development of induced pluripotent stem cellsYi ChenMeng LiYanqing WuThe ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc (OSKM), known as “Yamanaka factors,” can reprogram or stimulate the production of induced pluripotent stem cells (iPSCs). Although OSKM is still the gold standard, there are multiple ways to reprogram cells into iPSCs. In recent years, significant progress has been made in improving the efficiency of this technology. Ten years after the first report was published, human pluripotent stem cells have gradually been applied in clinical settings, including disease modeling, cell therapy, new drug development, and cell derivation. Here, we provide a review of the discovery of iPSCs and their applications in disease and development.https://www.frontiersin.org/articles/10.3389/fgene.2024.1389558/fullinduced pluripotent stem cellsiPSCsOSKMreprogramepigenetic barriers |
| spellingShingle | Yi Chen Meng Li Yanqing Wu The occurrence and development of induced pluripotent stem cells Frontiers in Genetics induced pluripotent stem cells iPSCs OSKM reprogram epigenetic barriers |
| title | The occurrence and development of induced pluripotent stem cells |
| title_full | The occurrence and development of induced pluripotent stem cells |
| title_fullStr | The occurrence and development of induced pluripotent stem cells |
| title_full_unstemmed | The occurrence and development of induced pluripotent stem cells |
| title_short | The occurrence and development of induced pluripotent stem cells |
| title_sort | occurrence and development of induced pluripotent stem cells |
| topic | induced pluripotent stem cells iPSCs OSKM reprogram epigenetic barriers |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1389558/full |
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