Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry
The study of the neural bases of eating behavior, hunger, and reward has consistently implicated the lateral hypothalamus (LH) and its interactions with mesocorticolimbic circuitry, such as mesolimbic dopamine projections to nucleus accumbens (NAc) and ventral pallidum (VP), in controlling motivatio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-06-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00090/full |
| _version_ | 1823936883112017920 |
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| author | Daniel Charles Castro Shannon eCole Kent eBerridge |
| author_facet | Daniel Charles Castro Shannon eCole Kent eBerridge |
| author_sort | Daniel Charles Castro |
| collection | DOAJ |
| description | The study of the neural bases of eating behavior, hunger, and reward has consistently implicated the lateral hypothalamus (LH) and its interactions with mesocorticolimbic circuitry, such as mesolimbic dopamine projections to nucleus accumbens (NAc) and ventral pallidum (VP), in controlling motivation to eat. The NAc and VP play special roles in mediating the hedonic impact (‘liking’) and motivational incentive salience (‘wanting’) of food rewards, and their interactions with LH help permit regulatory hunger/satiety modulation of food motivation and reward. Here, we review some progress that has been made regarding this circuitry and its functions: the identification of localized anatomical hedonic hotspots within NAc and VP for enhancing hedonic impact; interactions of NAc/VP hedonic hotspots with specific LH signals such as orexin; an anterior-posterior gradient of sites in NAc shell for producing intense appetitive eating versus intense fearful reactions; and anatomically distributed appetitive functions of dopamine and mu opioid signals in NAc shell and related structures. Such findings help improve our understanding of NAc, VP, and LH interactions in mediating affective and motivation functions, including ‘liking’ and ‘wanting’ for food rewards. |
| first_indexed | 2024-12-16T22:54:51Z |
| format | Article |
| id | doaj.art-267a6a477c1f46928a59d06791493a47 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-16T22:54:51Z |
| publishDate | 2015-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-267a6a477c1f46928a59d06791493a472022-12-21T22:12:56ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372015-06-01910.3389/fnsys.2015.00090111947Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitryDaniel Charles Castro0Shannon eCole1Kent eBerridge2University of MichiganUniversity of MichiganUniversity of MichiganThe study of the neural bases of eating behavior, hunger, and reward has consistently implicated the lateral hypothalamus (LH) and its interactions with mesocorticolimbic circuitry, such as mesolimbic dopamine projections to nucleus accumbens (NAc) and ventral pallidum (VP), in controlling motivation to eat. The NAc and VP play special roles in mediating the hedonic impact (‘liking’) and motivational incentive salience (‘wanting’) of food rewards, and their interactions with LH help permit regulatory hunger/satiety modulation of food motivation and reward. Here, we review some progress that has been made regarding this circuitry and its functions: the identification of localized anatomical hedonic hotspots within NAc and VP for enhancing hedonic impact; interactions of NAc/VP hedonic hotspots with specific LH signals such as orexin; an anterior-posterior gradient of sites in NAc shell for producing intense appetitive eating versus intense fearful reactions; and anatomically distributed appetitive functions of dopamine and mu opioid signals in NAc shell and related structures. Such findings help improve our understanding of NAc, VP, and LH interactions in mediating affective and motivation functions, including ‘liking’ and ‘wanting’ for food rewards.http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00090/fullMotivationNucleus AccumbensRewardventral pallidumlateral hypothalamus |
| spellingShingle | Daniel Charles Castro Shannon eCole Kent eBerridge Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry Frontiers in Systems Neuroscience Motivation Nucleus Accumbens Reward ventral pallidum lateral hypothalamus |
| title | Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry |
| title_full | Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry |
| title_fullStr | Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry |
| title_full_unstemmed | Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry |
| title_short | Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry |
| title_sort | lateral hypothalamus nucleus accumbens and ventral pallidum roles in eating and hunger interactions between homeostatic and reward circuitry |
| topic | Motivation Nucleus Accumbens Reward ventral pallidum lateral hypothalamus |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00090/full |
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