CLINICAL AND PATHOLOGICAL SIGNIFICANCE OF S100A4 EXPRESSION IN COLON CANCER
Aim: Because the S100A4 gene is recognized as a marker in metastasis (in vitro, in vivo) and invasion, this study aimed to determine the clinical and pathological significance of S100A4 expression in patients...
| Format: | Article |
|---|---|
| Language: | English |
| Published: |
Mustafa Kemal University
2016-12-01
|
| Series: | Mustafa Kemal Üniversitesi Tıp Dergisi |
| Subjects: | |
| Online Access: | http://dergipark.gov.tr/mkutfd/issue/19607/209604?publisher=mku |
| _version_ | 1797913173362212864 |
|---|---|
| collection | DOAJ |
| description | Aim: Because the S100A4 gene is recognized
as a marker in metastasis (in vitro, in vivo) and invasion, this study aimed to
determine the clinical and pathological significance of S100A4 expression in patients
with colorectal cancer.
Material and Methods: S100A4
expression was evaluated through samples taken from blocked resection material
from 111 colon cancer patients and through immunohistochemical staining scores
(IHCSS). We studied the relationships between IHCSS and patient age, gender,
tumor localization, tumor diameter, surgical procedure, perineural invasion,
perivascular invasion, T stage, N stage, M stage, disease stage, tumor grade,
and metastatic lymph node ratio, comparing survival and mortality rates.
Results: No statistically significant
difference was spotted when comparing IHCSS against patient gender, patient
age, tumor localization, surgery performed, or tumor diameter. As for
perivascular invasion, lymph node involvement, and degree of metastasis, all of
which are considered to intensify tumor progression and aggressivity, each
increased in direct proportion to IHCSS. As a result, because S100A4 expression
influences tumor metastasis and invasion, an increase in S100A4 proteins may herald
a poor prognosis.
Conclusion: Thus, S100A4 expression may be useful
for determining more effective treatment strategies in colorectal cancer.
Further studies are needed at the clinical level to confirm the practicality of
using S100A4 expression to augment patient treatment. |
| first_indexed | 2024-04-10T12:07:40Z |
| format | Article |
| id | doaj.art-267abb3be56e4c6286343bd30ca26198 |
| institution | Directory Open Access Journal |
| issn | 2149-3103 |
| language | English |
| last_indexed | 2024-04-10T12:07:40Z |
| publishDate | 2016-12-01 |
| publisher | Mustafa Kemal University |
| record_format | Article |
| series | Mustafa Kemal Üniversitesi Tıp Dergisi |
| spelling | doaj.art-267abb3be56e4c6286343bd30ca261982023-02-15T16:16:08ZengMustafa Kemal UniversityMustafa Kemal Üniversitesi Tıp Dergisi2149-31032016-12-0172871610.17944/mkutfd.209604102CLINICAL AND PATHOLOGICAL SIGNIFICANCE OF S100A4 EXPRESSION IN COLON CANCERAim: Because the S100A4 gene is recognized as a marker in metastasis (in vitro, in vivo) and invasion, this study aimed to determine the clinical and pathological significance of S100A4 expression in patients with colorectal cancer. Material and Methods: S100A4 expression was evaluated through samples taken from blocked resection material from 111 colon cancer patients and through immunohistochemical staining scores (IHCSS). We studied the relationships between IHCSS and patient age, gender, tumor localization, tumor diameter, surgical procedure, perineural invasion, perivascular invasion, T stage, N stage, M stage, disease stage, tumor grade, and metastatic lymph node ratio, comparing survival and mortality rates. Results: No statistically significant difference was spotted when comparing IHCSS against patient gender, patient age, tumor localization, surgery performed, or tumor diameter. As for perivascular invasion, lymph node involvement, and degree of metastasis, all of which are considered to intensify tumor progression and aggressivity, each increased in direct proportion to IHCSS. As a result, because S100A4 expression influences tumor metastasis and invasion, an increase in S100A4 proteins may herald a poor prognosis. Conclusion: Thus, S100A4 expression may be useful for determining more effective treatment strategies in colorectal cancer. Further studies are needed at the clinical level to confirm the practicality of using S100A4 expression to augment patient treatment.http://dergipark.gov.tr/mkutfd/issue/19607/209604?publisher=mkuKolon kanseriS100A4kalsiyum bağlayıcı proteinlerColon cancerS100A4calcium binding protein |
| spellingShingle | CLINICAL AND PATHOLOGICAL SIGNIFICANCE OF S100A4 EXPRESSION IN COLON CANCER Mustafa Kemal Üniversitesi Tıp Dergisi Kolon kanseri S100A4 kalsiyum bağlayıcı proteinler Colon cancer S100A4 calcium binding protein |
| title | CLINICAL AND PATHOLOGICAL SIGNIFICANCE OF S100A4 EXPRESSION IN COLON CANCER |
| title_full | CLINICAL AND PATHOLOGICAL SIGNIFICANCE OF S100A4 EXPRESSION IN COLON CANCER |
| title_fullStr | CLINICAL AND PATHOLOGICAL SIGNIFICANCE OF S100A4 EXPRESSION IN COLON CANCER |
| title_full_unstemmed | CLINICAL AND PATHOLOGICAL SIGNIFICANCE OF S100A4 EXPRESSION IN COLON CANCER |
| title_short | CLINICAL AND PATHOLOGICAL SIGNIFICANCE OF S100A4 EXPRESSION IN COLON CANCER |
| title_sort | clinical and pathological significance of s100a4 expression in colon cancer |
| topic | Kolon kanseri S100A4 kalsiyum bağlayıcı proteinler Colon cancer S100A4 calcium binding protein |
| url | http://dergipark.gov.tr/mkutfd/issue/19607/209604?publisher=mku |