ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein
An NMR-centered approach demonstrates that the liquid-liquid phase separation behavior of the SARS-CoV-2 nucleocapsid (N) protein is modulated by competitive interactions with ATP and nucleic acids.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04480-3 |
| _version_ | 1797945723673640960 |
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| author | Mei Dang Tongyang Li Jianxing Song |
| author_facet | Mei Dang Tongyang Li Jianxing Song |
| author_sort | Mei Dang |
| collection | DOAJ |
| description | An NMR-centered approach demonstrates that the liquid-liquid phase separation behavior of the SARS-CoV-2 nucleocapsid (N) protein is modulated by competitive interactions with ATP and nucleic acids. |
| first_indexed | 2024-04-10T20:59:37Z |
| format | Article |
| id | doaj.art-267d4e46261347688e35b2d113ff9789 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-10T20:59:37Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-267d4e46261347688e35b2d113ff97892023-01-22T12:22:10ZengNature PortfolioCommunications Biology2399-36422023-01-016111110.1038/s42003-023-04480-3ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid proteinMei Dang0Tongyang Li1Jianxing Song2Department of Biological Sciences, Faculty of Science, National University of SingaporeDepartment of Biological Sciences, Faculty of Science, National University of SingaporeDepartment of Biological Sciences, Faculty of Science, National University of SingaporeAn NMR-centered approach demonstrates that the liquid-liquid phase separation behavior of the SARS-CoV-2 nucleocapsid (N) protein is modulated by competitive interactions with ATP and nucleic acids.https://doi.org/10.1038/s42003-023-04480-3 |
| spellingShingle | Mei Dang Tongyang Li Jianxing Song ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein Communications Biology |
| title | ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein |
| title_full | ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein |
| title_fullStr | ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein |
| title_full_unstemmed | ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein |
| title_short | ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein |
| title_sort | atp and nucleic acids competitively modulate llps of the sars cov2 nucleocapsid protein |
| url | https://doi.org/10.1038/s42003-023-04480-3 |
| work_keys_str_mv | AT meidang atpandnucleicacidscompetitivelymodulatellpsofthesarscov2nucleocapsidprotein AT tongyangli atpandnucleicacidscompetitivelymodulatellpsofthesarscov2nucleocapsidprotein AT jianxingsong atpandnucleicacidscompetitivelymodulatellpsofthesarscov2nucleocapsidprotein |