ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein

An NMR-centered approach demonstrates that the liquid-liquid phase separation behavior of the SARS-CoV-2 nucleocapsid (N) protein is modulated by competitive interactions with ATP and nucleic acids.

Bibliographic Details
Main Authors: Mei Dang, Tongyang Li, Jianxing Song
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04480-3