Hodgkin Lymphoma: Biology and Differential Diagnostic Problem
Hodgkin lymphomas (HLs) are lymphoid neoplasms that are morphologically defined as being composed of dysplastic cells, namely, Hodgkin and Reed–Sternberg cells, in a reactive inflammatory background. The biological nature of HLs has long been unclear; however, our understanding of HL-related genetic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/6/1507 |
| _version_ | 1797488229433212928 |
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| author | Taishi Takahara Akira Satou Toyonori Tsuzuki Shigeo Nakamura |
| author_facet | Taishi Takahara Akira Satou Toyonori Tsuzuki Shigeo Nakamura |
| author_sort | Taishi Takahara |
| collection | DOAJ |
| description | Hodgkin lymphomas (HLs) are lymphoid neoplasms that are morphologically defined as being composed of dysplastic cells, namely, Hodgkin and Reed–Sternberg cells, in a reactive inflammatory background. The biological nature of HLs has long been unclear; however, our understanding of HL-related genetics and tumor microenvironment interactions is rapidly expanding. For example, cell surface overexpression of programmed cell death 1 ligand 1 (CD274/PD-L1) is now considered a defining feature of an HL subset, and targeting such immune checkpoint molecules is a promising therapeutic option. Still, HLs comprise multiple disease subtypes, and some HL features may overlap with its morphological mimics, posing challenging diagnostic and therapeutic problems. In this review, we summarize the recent advances in understanding the biology of HLs, and discuss approaches to differentiating HL and its mimics. |
| first_indexed | 2024-03-09T23:59:05Z |
| format | Article |
| id | doaj.art-267d95ce758b48718f5002fe0ee6eaf2 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T23:59:05Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-267d95ce758b48718f5002fe0ee6eaf22023-11-23T16:19:20ZengMDPI AGDiagnostics2075-44182022-06-01126150710.3390/diagnostics12061507Hodgkin Lymphoma: Biology and Differential Diagnostic ProblemTaishi Takahara0Akira Satou1Toyonori Tsuzuki2Shigeo Nakamura3Department of Surgical Pathology, Aichi Medical University, Nagakute 480-1195, JapanDepartment of Surgical Pathology, Aichi Medical University, Nagakute 480-1195, JapanDepartment of Surgical Pathology, Aichi Medical University, Nagakute 480-1195, JapanDepartment of Pathology and Laboratory Medicine, Nagoya University, Nagoya 464-8601, JapanHodgkin lymphomas (HLs) are lymphoid neoplasms that are morphologically defined as being composed of dysplastic cells, namely, Hodgkin and Reed–Sternberg cells, in a reactive inflammatory background. The biological nature of HLs has long been unclear; however, our understanding of HL-related genetics and tumor microenvironment interactions is rapidly expanding. For example, cell surface overexpression of programmed cell death 1 ligand 1 (CD274/PD-L1) is now considered a defining feature of an HL subset, and targeting such immune checkpoint molecules is a promising therapeutic option. Still, HLs comprise multiple disease subtypes, and some HL features may overlap with its morphological mimics, posing challenging diagnostic and therapeutic problems. In this review, we summarize the recent advances in understanding the biology of HLs, and discuss approaches to differentiating HL and its mimics.https://www.mdpi.com/2075-4418/12/6/1507Hodgkin lymphomageneticstumor microenvironment |
| spellingShingle | Taishi Takahara Akira Satou Toyonori Tsuzuki Shigeo Nakamura Hodgkin Lymphoma: Biology and Differential Diagnostic Problem Diagnostics Hodgkin lymphoma genetics tumor microenvironment |
| title | Hodgkin Lymphoma: Biology and Differential Diagnostic Problem |
| title_full | Hodgkin Lymphoma: Biology and Differential Diagnostic Problem |
| title_fullStr | Hodgkin Lymphoma: Biology and Differential Diagnostic Problem |
| title_full_unstemmed | Hodgkin Lymphoma: Biology and Differential Diagnostic Problem |
| title_short | Hodgkin Lymphoma: Biology and Differential Diagnostic Problem |
| title_sort | hodgkin lymphoma biology and differential diagnostic problem |
| topic | Hodgkin lymphoma genetics tumor microenvironment |
| url | https://www.mdpi.com/2075-4418/12/6/1507 |
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