Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn
Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by antigenic incompatibility of platelets between a pregnant woman and her child, resulting in producing antibodies by a mother against specific antigens (HPA- Human Platelet Antigens) located on fetal platelets inherited from his fat...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2018-12-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/26399 |
| _version_ | 1829113484170756096 |
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| author | Maciej Kamiński Paulina Grzesik Monika Długoń Maciej Majsterek Żaneta Kimber-Trojnar Krzysztof Kamiński Bożena Leszczyńska-Gorzelak |
| author_facet | Maciej Kamiński Paulina Grzesik Monika Długoń Maciej Majsterek Żaneta Kimber-Trojnar Krzysztof Kamiński Bożena Leszczyńska-Gorzelak |
| author_sort | Maciej Kamiński |
| collection | DOAJ |
| description | Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by antigenic incompatibility of platelets between a pregnant woman and her child, resulting in producing antibodies by a mother against specific antigens (HPA- Human Platelet Antigens) located on fetal platelets inherited from his father.
The aim of this study is to present a 29-year-old patient in the 40th week of the second pregnancy admitted to the Department after rupturing of membranes. A male infant was born vaginally with numerous petechiae, bruising and yellowish skin colour. Due to severe thrombocytopenia 1 unit of leucocyte-reduced, irradiated, reconstituted platelet concentrate (LRIRPC) of blood group O RhD (+), suspended in plasma type AB was ordered. Human immunoglobulin (Kiovig preparation) was transfused. A check exam of complete blood count of the newborn revealed 5 x 103/µL of platelets count 4 hours after the transfusion. Following transfusions of LRIRPC and Kiovig were ordered. Again with no therapeutic effect. The newborn’s HPA antigens were identified as: 1a/b; 2a/a; 3a/a; 5a/a; 4a/a; 15b/b, platelet antibodies derived from the mother were found in his serum. After transfusion of 1 unit of HPA-1b/b LRIRPC at 37 hours of the newborn’s life the platelet count increased to 67 x103/µL. The treatment with dexamethasone and Kiovig was continued. The infant was discharged in good condition in the 33rd day of life.
The FNAIT diagnostics is usually carried out only as a result of clinical manifestations of thrombocytopenia in the newborn. There was a possibility for all pregnant women from 8 weeks of pregnancy to have their blood tested for the presence of HPA-1a antigen in the period between October of 2013 to January of 2017 in Poland. It made it possible to nominate HPA-1a negative women. |
| first_indexed | 2024-12-12T15:37:05Z |
| format | Article |
| id | doaj.art-26801e827a244b7aa03ba67963adb3cf |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-12T15:37:05Z |
| publishDate | 2018-12-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-26801e827a244b7aa03ba67963adb3cf2022-12-22T00:19:58ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062018-12-01812Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newbornMaciej Kamiński0Paulina Grzesik1Monika Długoń2Maciej Majsterek3Żaneta Kimber-Trojnar4Krzysztof Kamiński5Bożena Leszczyńska-Gorzelak6Medical University of LublinMedical University of LublinMedical University of LublinMedical University of LublinMedical University of LublinMedical University of LublinMedical University of LublinFoetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by antigenic incompatibility of platelets between a pregnant woman and her child, resulting in producing antibodies by a mother against specific antigens (HPA- Human Platelet Antigens) located on fetal platelets inherited from his father. The aim of this study is to present a 29-year-old patient in the 40th week of the second pregnancy admitted to the Department after rupturing of membranes. A male infant was born vaginally with numerous petechiae, bruising and yellowish skin colour. Due to severe thrombocytopenia 1 unit of leucocyte-reduced, irradiated, reconstituted platelet concentrate (LRIRPC) of blood group O RhD (+), suspended in plasma type AB was ordered. Human immunoglobulin (Kiovig preparation) was transfused. A check exam of complete blood count of the newborn revealed 5 x 103/µL of platelets count 4 hours after the transfusion. Following transfusions of LRIRPC and Kiovig were ordered. Again with no therapeutic effect. The newborn’s HPA antigens were identified as: 1a/b; 2a/a; 3a/a; 5a/a; 4a/a; 15b/b, platelet antibodies derived from the mother were found in his serum. After transfusion of 1 unit of HPA-1b/b LRIRPC at 37 hours of the newborn’s life the platelet count increased to 67 x103/µL. The treatment with dexamethasone and Kiovig was continued. The infant was discharged in good condition in the 33rd day of life. The FNAIT diagnostics is usually carried out only as a result of clinical manifestations of thrombocytopenia in the newborn. There was a possibility for all pregnant women from 8 weeks of pregnancy to have their blood tested for the presence of HPA-1a antigen in the period between October of 2013 to January of 2017 in Poland. It made it possible to nominate HPA-1a negative women.https://apcz.umk.pl/JEHS/article/view/26399ThrombocytopeniaHPAFNAIT |
| spellingShingle | Maciej Kamiński Paulina Grzesik Monika Długoń Maciej Majsterek Żaneta Kimber-Trojnar Krzysztof Kamiński Bożena Leszczyńska-Gorzelak Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn Journal of Education, Health and Sport Thrombocytopenia HPA FNAIT |
| title | Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn |
| title_full | Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn |
| title_fullStr | Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn |
| title_full_unstemmed | Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn |
| title_short | Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn |
| title_sort | foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn |
| topic | Thrombocytopenia HPA FNAIT |
| url | https://apcz.umk.pl/JEHS/article/view/26399 |
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