Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.
<h4>Background</h4>The life expectancy of people living with HIV (PLWH) remains shorter than that of the general population, despite significant improvement in the recent years. Mortality in HIV-infected individuals may be associated with a higher viral load at of diagnosis, a lower CD4...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0255834 |
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| author | Bogusz Jan Aksak-Wąs Miłosz Parczewski Anna Urbańska Małgorzata Hackiewicz Justyna D Kowalska |
| author_facet | Bogusz Jan Aksak-Wąs Miłosz Parczewski Anna Urbańska Małgorzata Hackiewicz Justyna D Kowalska |
| author_sort | Bogusz Jan Aksak-Wąs |
| collection | DOAJ |
| description | <h4>Background</h4>The life expectancy of people living with HIV (PLWH) remains shorter than that of the general population, despite significant improvement in the recent years. Mortality in HIV-infected individuals may be associated with a higher viral load at of diagnosis, a lower CD4 count, or clinical variables such as sex or route of transmission. This article investigated the role of the HLA-B*5701 varian on mortality among PLWH.<h4>Methods</h4>Material for the analysis consist of the data of 2,393 patients for whom the HLA-B*57 variant was known. Those patients were followed under the care of the Infectious Diseases Hospital in Warsaw (n = 1555) and the Clinic of Acquired Immunodeficiency of the Pomeranian Medical University in Szczecin (n = 838). Factors such as age, gender, date of HIV diagnosis, route of transmission, date of death, baseline HIV viral load and baseline CD4 counts, were collected, and end-point cross-sectional analyses were marked at 60, 120, 180 and 240 month of observation.<h4>Results</h4>HLA-B*5701 allele was found in 133 (5.5%) analyzed cases. Median age was notably higher for HLA-B*5701 positive patients [32.7 (28.3-41.3) vs. 31.6 (26.8-38.3)years p = 0.02]. HLA-B*5701 was associated with lower baseline viral load [4.21 (3.5-4.8) vs. 4.79 (4.2-5.3)log copies/ml p<0.001] and higher CD4count [448 (294.5-662) vs. 352 (176-514) cells/μl p<0.001]. There were no association between HLA-B*5701 and survival for any given end-point. Higher mortality was associated to male gender, intravenous drug users, lower CD4 count at baseline and higher baseline viral load.<h4>Conclusions</h4>In our study, the presence of HLA-B*5701 allel was not associated with mortality rate of HIV infected patients, irrespective of being associated with both higher baseline CD4 + cell count and lower baseline HIV viral load. |
| first_indexed | 2024-04-13T11:33:44Z |
| format | Article |
| id | doaj.art-2680cbe99157415383d749e64dff8905 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T11:33:44Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2680cbe99157415383d749e64dff89052022-12-22T02:48:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01168e025583410.1371/journal.pone.0255834Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.Bogusz Jan Aksak-WąsMiłosz ParczewskiAnna UrbańskaMałgorzata HackiewiczJustyna D Kowalska<h4>Background</h4>The life expectancy of people living with HIV (PLWH) remains shorter than that of the general population, despite significant improvement in the recent years. Mortality in HIV-infected individuals may be associated with a higher viral load at of diagnosis, a lower CD4 count, or clinical variables such as sex or route of transmission. This article investigated the role of the HLA-B*5701 varian on mortality among PLWH.<h4>Methods</h4>Material for the analysis consist of the data of 2,393 patients for whom the HLA-B*57 variant was known. Those patients were followed under the care of the Infectious Diseases Hospital in Warsaw (n = 1555) and the Clinic of Acquired Immunodeficiency of the Pomeranian Medical University in Szczecin (n = 838). Factors such as age, gender, date of HIV diagnosis, route of transmission, date of death, baseline HIV viral load and baseline CD4 counts, were collected, and end-point cross-sectional analyses were marked at 60, 120, 180 and 240 month of observation.<h4>Results</h4>HLA-B*5701 allele was found in 133 (5.5%) analyzed cases. Median age was notably higher for HLA-B*5701 positive patients [32.7 (28.3-41.3) vs. 31.6 (26.8-38.3)years p = 0.02]. HLA-B*5701 was associated with lower baseline viral load [4.21 (3.5-4.8) vs. 4.79 (4.2-5.3)log copies/ml p<0.001] and higher CD4count [448 (294.5-662) vs. 352 (176-514) cells/μl p<0.001]. There were no association between HLA-B*5701 and survival for any given end-point. Higher mortality was associated to male gender, intravenous drug users, lower CD4 count at baseline and higher baseline viral load.<h4>Conclusions</h4>In our study, the presence of HLA-B*5701 allel was not associated with mortality rate of HIV infected patients, irrespective of being associated with both higher baseline CD4 + cell count and lower baseline HIV viral load.https://doi.org/10.1371/journal.pone.0255834 |
| spellingShingle | Bogusz Jan Aksak-Wąs Miłosz Parczewski Anna Urbańska Małgorzata Hackiewicz Justyna D Kowalska Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV. PLoS ONE |
| title | Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV. |
| title_full | Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV. |
| title_fullStr | Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV. |
| title_full_unstemmed | Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV. |
| title_short | Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV. |
| title_sort | influence of hla b 5701 on 20 year survival rate among patients living with hiv |
| url | https://doi.org/10.1371/journal.pone.0255834 |
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