Improved Protocol Toward 1,3,4-Oxadiazole-2(3H)-thiones and Scale-up Synthesis in the Presence of SDS as a Micelle Promoted Catalyst
Convenient procedure for in situ cyclization of hydrazinecarbodithioate potassium salts to 1,3,4-oxadiazole-2(3H)-thiones under normal phase micellar media catalysis promoted by sodium dodecyl sulfate (SDS) as an anionic surfactant is reported. The main advantages of this procedure is to provide sho...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Slovenian Chemical Society
2015-04-01
|
| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/1100 |
| Summary: | Convenient procedure for in situ cyclization of hydrazinecarbodithioate potassium salts to 1,3,4-oxadiazole-2(3H)-thiones under normal phase micellar media catalysis promoted by sodium dodecyl sulfate (SDS) as an anionic surfactant is reported. The main advantages of this procedure is to provide shorter reaction time for the completion of cyclization, scale-up synthesis is possible and the oxadiazoles were obtained in high to excellent yields (87-100%), making the protocol an alternative addition to the available methods. |
|---|---|
| ISSN: | 1318-0207 1580-3155 |