PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel
Purpose: In the present study, to achieve high paclitaxel (PTX) loading in a conjugated drug delivery system with minimal long-term side effects, we formulated a novel degradable stereocomplexed micelle-like particle with a core-shell structure. Materials and methods: In this system, methoxy polyeth...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2021-09-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/26/9/10.52586/4964 |
| _version_ | 1818355043833741312 |
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| author | Yuemin Wang Siyuan Cui Bing Wu Quanxing Zhang Wei Jiang |
| author_facet | Yuemin Wang Siyuan Cui Bing Wu Quanxing Zhang Wei Jiang |
| author_sort | Yuemin Wang |
| collection | DOAJ |
| description | Purpose: In the present study, to achieve high paclitaxel (PTX) loading in a conjugated drug delivery system with minimal long-term side effects, we formulated a novel degradable stereocomplexed micelle-like particle with a core-shell structure. Materials and methods: In this system, methoxy polyethylene glycol (MPEG) acted as the hydrophilic shell, and the stereocomplex of polylactic acid with PTX (SCPLA-PTX) acted as the hydrophobic core. The MPEG-SCPLA-PTX micelle-like particles were synthesized via the self-assembly of a MPEG-poly l-lactic acid (PLLA) copolymer with a PTX-poly d-lactic acid-PTX copolymer. The resultant copolymers and their intermediates were characterized using 1H nuclear magnetic resonance and GPC. Micelle-like particles with different molecular weight ratios of MPEG and PLLA were synthesized to demonstrate the functions of both components. Results: PTX loading into MPEG2000Da-PLLA6000Da particles reached as high as 20.11%. At 216 h, the cumulative release from MPEG5000Da-PLLA6000Da, MPEG2000Da-PLLA6000Da, and MPEG5000Da-PLLA22000Da particles were 51.5%, 37.7%, and 52.0%, respectively. Conclusions: According to the cell uptake experiments, inhibition of tumor cell growth was satisfactory, indicating that the stereocomplexed particles developed in the present study can be employed as a promising nanocarrier for PTX delivery. |
| first_indexed | 2024-12-13T19:35:03Z |
| format | Article |
| id | doaj.art-2687637b6f24404ca5c84fdd9e396585 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-13T19:35:03Z |
| publishDate | 2021-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-2687637b6f24404ca5c84fdd9e3965852022-12-21T23:33:50ZengIMR PressFrontiers in Bioscience-Landmark2768-67012021-09-0126951753210.52586/4964s2768-6701(21)00025-3PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxelYuemin Wang0Siyuan Cui1Bing Wu2Quanxing Zhang3Wei Jiang4State Key Laboratory of Pollution Control and Resources Reuse, National Engineering Research Center for Organic Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210023 Nanjing, Jiangsu, ChinaState Key Laboratory of Pollution Control and Resources Reuse, National Engineering Research Center for Organic Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210023 Nanjing, Jiangsu, ChinaState Key Laboratory of Pollution Control and Resources Reuse, National Engineering Research Center for Organic Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210023 Nanjing, Jiangsu, ChinaState Key Laboratory of Pollution Control and Resources Reuse, National Engineering Research Center for Organic Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210023 Nanjing, Jiangsu, ChinaState Key Laboratory of Pollution Control and Resources Reuse, National Engineering Research Center for Organic Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210023 Nanjing, Jiangsu, ChinaPurpose: In the present study, to achieve high paclitaxel (PTX) loading in a conjugated drug delivery system with minimal long-term side effects, we formulated a novel degradable stereocomplexed micelle-like particle with a core-shell structure. Materials and methods: In this system, methoxy polyethylene glycol (MPEG) acted as the hydrophilic shell, and the stereocomplex of polylactic acid with PTX (SCPLA-PTX) acted as the hydrophobic core. The MPEG-SCPLA-PTX micelle-like particles were synthesized via the self-assembly of a MPEG-poly l-lactic acid (PLLA) copolymer with a PTX-poly d-lactic acid-PTX copolymer. The resultant copolymers and their intermediates were characterized using 1H nuclear magnetic resonance and GPC. Micelle-like particles with different molecular weight ratios of MPEG and PLLA were synthesized to demonstrate the functions of both components. Results: PTX loading into MPEG2000Da-PLLA6000Da particles reached as high as 20.11%. At 216 h, the cumulative release from MPEG5000Da-PLLA6000Da, MPEG2000Da-PLLA6000Da, and MPEG5000Da-PLLA22000Da particles were 51.5%, 37.7%, and 52.0%, respectively. Conclusions: According to the cell uptake experiments, inhibition of tumor cell growth was satisfactory, indicating that the stereocomplexed particles developed in the present study can be employed as a promising nanocarrier for PTX delivery.https://www.imrpress.com/journal/FBL/26/9/10.52586/4964paclitaxelmpeg-pllastereocomplexnanoparticlescontrollable drug loading |
| spellingShingle | Yuemin Wang Siyuan Cui Bing Wu Quanxing Zhang Wei Jiang PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel Frontiers in Bioscience-Landmark paclitaxel mpeg-plla stereocomplex nanoparticles controllable drug loading |
| title | PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel |
| title_full | PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel |
| title_fullStr | PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel |
| title_full_unstemmed | PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel |
| title_short | PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel |
| title_sort | pla based core shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel |
| topic | paclitaxel mpeg-plla stereocomplex nanoparticles controllable drug loading |
| url | https://www.imrpress.com/journal/FBL/26/9/10.52586/4964 |
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