Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1

Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1

IntroductionUltraviolet (UV) light is a known trigger of both cutaneous and systemic disease manifestations in lupus patients. Lupus skin has elevated expression of type I interferons (IFNs) that promote increased keratinocyte (KC) death after UV exposure. The mechanisms by which KC cell death is in...

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Bibliographic Details
Main Authors: Shannon N. Loftus, Mehrnaz Gharaee-Kermani, Bin Xu, Tyson M. Moore, Andrew Hannoudi, Mischa J. Mallbris, Benjamin Klein, Johann E. Gudjonsson, J. Michelle Kahlenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
interferon
apoptosis
ultraviolet light
keratinocyte
lupus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1384606/full

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