Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study
Abstract Background The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact on discomfort of ICU patients. Methods This randomized multicenter non-i...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-12-01
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| Series: | Annals of Intensive Care |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13613-018-0472-9 |
| _version_ | 1818899140860444672 |
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| author | Laurent Poiroux Lise Piquilloud Valérie Seegers Cyril Le Roy Karine Colonval Carole Agasse Vanessa Zinzoni Vanessa Hodebert Alexandre Cambonie Josselin Saletes Irma Bourgeon François Beloncle Alain Mercat for the REVA Network |
| author_facet | Laurent Poiroux Lise Piquilloud Valérie Seegers Cyril Le Roy Karine Colonval Carole Agasse Vanessa Zinzoni Vanessa Hodebert Alexandre Cambonie Josselin Saletes Irma Bourgeon François Beloncle Alain Mercat for the REVA Network |
| author_sort | Laurent Poiroux |
| collection | DOAJ |
| description | Abstract Background The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact on discomfort of ICU patients. Methods This randomized multicenter non-inferiority open trial included patients admitted in intensive care unit and receiving oxygen. Any patient receiving non-humidified oxygen (between 0 and 15 L/min) for less than 2 h could participate in the study. Randomization was stratified based on the flow rate at inclusion (less or more than 4 L/min). Discomfort was assessed 6–8 and 24 h after inclusion using a dedicated 15-item scale (quoted from 0 to 150). Results Three hundred and fifty-four ICU patients receiving non-humidified oxygen were randomized either in the humidified (HO) (n = 172), using bubble humidifiers, or in the non-humidified (NHO) (n = 182) arms. In modified intention-to-treat analysis at H6–H8, the 15-item score was 26.6 ± 19.4 and 29.8 ± 23.4 in the HO and NHO groups, respectively. The absolute difference between scores in both groups was 3.2 [90% CI 0.0; + 6.5] for a non-inferiority margin of 5.3, meaning that the non-inferiority analysis was not conclusive. This was also true for the subgroups of patients receiving either less or more than 4 L/min of oxygen. At H24, using NHO was not inferior compared to HO in the general population and in the subgroup of patients receiving 4 L/min or less of oxygen. However, for patients receiving more than 4 L/min, a post hoc superiority analysis suggested that patients receiving dry oxygen were less comfortable. Conclusions Oxygen therapy-related discomfort was low. Dry oxygen could not be demonstrated as non-inferior compared to bubble-moistened oxygen after 6–8 h of oxygen administration. At 24 h, dry oxygen was non-inferior compared to bubble-humidified oxygen for flows below 4 L/min. |
| first_indexed | 2024-12-19T19:43:14Z |
| format | Article |
| id | doaj.art-2689c837f0114d44b2e90e41690229ec |
| institution | Directory Open Access Journal |
| issn | 2110-5820 |
| language | English |
| last_indexed | 2024-12-19T19:43:14Z |
| publishDate | 2018-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Annals of Intensive Care |
| spelling | doaj.art-2689c837f0114d44b2e90e41690229ec2022-12-21T20:08:12ZengSpringerOpenAnnals of Intensive Care2110-58202018-12-01811910.1186/s13613-018-0472-9Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized studyLaurent Poiroux0Lise Piquilloud1Valérie Seegers2Cyril Le Roy3Karine Colonval4Carole Agasse5Vanessa Zinzoni6Vanessa Hodebert7Alexandre Cambonie8Josselin Saletes9Irma Bourgeon10François Beloncle11Alain Mercat12for the REVA NetworkMedical Intensive Care Department, Angers University HospitalAdult Intensive Care and Burn Unit, Medical Intensive Care Department, Lausanne University HospitalDépartement de Biométrie, Institut de Cancérologie de l’OuestMedical Intensive Care Department, Angers University HospitalMedical Intensive Care Department, Orléans Regional HospitalMedical Intensive Care Department, Nantes University HospitalIntensive Care Department, La Roche-sur-Yon Hospital, Boulevard Stéphane MoreauIntensive Care Unit, Saint-Malo HospitalMedical Intensive Care Department, Poitiers University HospitalIntensive Care Unit, Le Mans HospitalMedical Intensive Care Department, Henri Mondor University HospitalMedical Intensive Care Department, Angers University HospitalMedical Intensive Care Department, Angers University HospitalAbstract Background The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact on discomfort of ICU patients. Methods This randomized multicenter non-inferiority open trial included patients admitted in intensive care unit and receiving oxygen. Any patient receiving non-humidified oxygen (between 0 and 15 L/min) for less than 2 h could participate in the study. Randomization was stratified based on the flow rate at inclusion (less or more than 4 L/min). Discomfort was assessed 6–8 and 24 h after inclusion using a dedicated 15-item scale (quoted from 0 to 150). Results Three hundred and fifty-four ICU patients receiving non-humidified oxygen were randomized either in the humidified (HO) (n = 172), using bubble humidifiers, or in the non-humidified (NHO) (n = 182) arms. In modified intention-to-treat analysis at H6–H8, the 15-item score was 26.6 ± 19.4 and 29.8 ± 23.4 in the HO and NHO groups, respectively. The absolute difference between scores in both groups was 3.2 [90% CI 0.0; + 6.5] for a non-inferiority margin of 5.3, meaning that the non-inferiority analysis was not conclusive. This was also true for the subgroups of patients receiving either less or more than 4 L/min of oxygen. At H24, using NHO was not inferior compared to HO in the general population and in the subgroup of patients receiving 4 L/min or less of oxygen. However, for patients receiving more than 4 L/min, a post hoc superiority analysis suggested that patients receiving dry oxygen were less comfortable. Conclusions Oxygen therapy-related discomfort was low. Dry oxygen could not be demonstrated as non-inferior compared to bubble-moistened oxygen after 6–8 h of oxygen administration. At 24 h, dry oxygen was non-inferior compared to bubble-humidified oxygen for flows below 4 L/min.http://link.springer.com/article/10.1186/s13613-018-0472-9Oxygen therapyBubble humidificationPatient comfortNursing assessmentIntensive care units |
| spellingShingle | Laurent Poiroux Lise Piquilloud Valérie Seegers Cyril Le Roy Karine Colonval Carole Agasse Vanessa Zinzoni Vanessa Hodebert Alexandre Cambonie Josselin Saletes Irma Bourgeon François Beloncle Alain Mercat for the REVA Network Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study Annals of Intensive Care Oxygen therapy Bubble humidification Patient comfort Nursing assessment Intensive care units |
| title | Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study |
| title_full | Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study |
| title_fullStr | Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study |
| title_full_unstemmed | Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study |
| title_short | Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study |
| title_sort | effect on comfort of administering bubble humidified or dry oxygen the oxyrea non inferiority randomized study |
| topic | Oxygen therapy Bubble humidification Patient comfort Nursing assessment Intensive care units |
| url | http://link.springer.com/article/10.1186/s13613-018-0472-9 |
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