Cell type specializations of the vocal-motor cortex in songbirds
Summary: Identifying molecular specializations in cortical circuitry supporting complex behaviors, like learned vocalizations, requires understanding of the neuroanatomical context from which these circuits arise. In songbirds, the robust arcopallial nucleus (RA) provides descending cortical project...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723013566 |
| _version_ | 1797448034838118400 |
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| author | Alexander A. Nevue Benjamin M. Zemel Samantha R. Friedrich Henrique von Gersdorff Claudio V. Mello |
| author_facet | Alexander A. Nevue Benjamin M. Zemel Samantha R. Friedrich Henrique von Gersdorff Claudio V. Mello |
| author_sort | Alexander A. Nevue |
| collection | DOAJ |
| description | Summary: Identifying molecular specializations in cortical circuitry supporting complex behaviors, like learned vocalizations, requires understanding of the neuroanatomical context from which these circuits arise. In songbirds, the robust arcopallial nucleus (RA) provides descending cortical projections for fine vocal-motor control. Using single-nuclei transcriptomics and spatial gene expression mapping in zebra finches, we have defined cell types and molecular specializations that distinguish RA from adjacent regions involved in non-vocal motor and sensory processing. We describe an RA-specific projection neuron, differential inhibitory subtypes, and glia specializations and have probed predicted GABAergic interneuron subtypes electrophysiologically within RA. Several cell-specific markers arise developmentally in a sex-dependent manner. Our interactive apps integrate cellular data with developmental and spatial distribution data from the gene expression brain atlas ZEBrA. Users can explore molecular specializations of vocal-motor neurons and support cells that likely reflect adaptations key to the physiology and evolution of vocal control circuits and refined motor skills. |
| first_indexed | 2024-03-09T14:04:34Z |
| format | Article |
| id | doaj.art-268d37ad7c2f4b3985808883a1b14380 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-09T14:04:34Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-268d37ad7c2f4b3985808883a1b143802023-11-30T05:06:52ZengElsevierCell Reports2211-12472023-11-014211113344Cell type specializations of the vocal-motor cortex in songbirdsAlexander A. Nevue0Benjamin M. Zemel1Samantha R. Friedrich2Henrique von Gersdorff3Claudio V. Mello4Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA; Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USAVollum Institute, Oregon Health & Science University, Portland, OR 97239, USADepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USAVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA; Corresponding authorDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA; Corresponding authorSummary: Identifying molecular specializations in cortical circuitry supporting complex behaviors, like learned vocalizations, requires understanding of the neuroanatomical context from which these circuits arise. In songbirds, the robust arcopallial nucleus (RA) provides descending cortical projections for fine vocal-motor control. Using single-nuclei transcriptomics and spatial gene expression mapping in zebra finches, we have defined cell types and molecular specializations that distinguish RA from adjacent regions involved in non-vocal motor and sensory processing. We describe an RA-specific projection neuron, differential inhibitory subtypes, and glia specializations and have probed predicted GABAergic interneuron subtypes electrophysiologically within RA. Several cell-specific markers arise developmentally in a sex-dependent manner. Our interactive apps integrate cellular data with developmental and spatial distribution data from the gene expression brain atlas ZEBrA. Users can explore molecular specializations of vocal-motor neurons and support cells that likely reflect adaptations key to the physiology and evolution of vocal control circuits and refined motor skills.http://www.sciencedirect.com/science/article/pii/S2211124723013566CP: Neuroscience |
| spellingShingle | Alexander A. Nevue Benjamin M. Zemel Samantha R. Friedrich Henrique von Gersdorff Claudio V. Mello Cell type specializations of the vocal-motor cortex in songbirds Cell Reports CP: Neuroscience |
| title | Cell type specializations of the vocal-motor cortex in songbirds |
| title_full | Cell type specializations of the vocal-motor cortex in songbirds |
| title_fullStr | Cell type specializations of the vocal-motor cortex in songbirds |
| title_full_unstemmed | Cell type specializations of the vocal-motor cortex in songbirds |
| title_short | Cell type specializations of the vocal-motor cortex in songbirds |
| title_sort | cell type specializations of the vocal motor cortex in songbirds |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723013566 |
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