Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City
<h4>Introduction</h4> We performed a longitudinal SARS-CoV-2 seroepidemiological study in healthcare personnel of the two largest tertiary COVID-19 referral hospitals in Mexico City. <h4>Methods</h4> All healthcare personnel, including staff physicians, physicians in training...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929624/?tool=EBI |
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| author | Vanessa Dávila-Conn Maribel Soto-Nava Yanink N. Caro-Vega Héctor E. Paz-Juárez Pedro García-Esparza Daniela Tapia-Trejo Marissa Pérez-García Pablo F. Belaunzarán-Zamudio Gustavo Reyes-Terán Juan G. Sierra-Madero Arturo Galindo-Fraga Santiago Ávila-Ríos |
| author_facet | Vanessa Dávila-Conn Maribel Soto-Nava Yanink N. Caro-Vega Héctor E. Paz-Juárez Pedro García-Esparza Daniela Tapia-Trejo Marissa Pérez-García Pablo F. Belaunzarán-Zamudio Gustavo Reyes-Terán Juan G. Sierra-Madero Arturo Galindo-Fraga Santiago Ávila-Ríos |
| author_sort | Vanessa Dávila-Conn |
| collection | DOAJ |
| description | <h4>Introduction</h4> We performed a longitudinal SARS-CoV-2 seroepidemiological study in healthcare personnel of the two largest tertiary COVID-19 referral hospitals in Mexico City. <h4>Methods</h4> All healthcare personnel, including staff physicians, physicians in training, nurses, laboratory technicians, researchers, students, housekeeping, maintenance, security, and administrative staff were invited to voluntarily participate, after written informed consent. Participants answered a computer-assisted self-administered interview and donated blood samples for antibody testing every three weeks from October 2020 to June 2021. <h4>Results</h4> A total of 883 participants (out of 3639 registered employees) contributed with at least one blood sample. The median age was 36 years (interquartile range: 28–46) and 70% were women. The most common occupations were nurse (28%), physician (24%), and administrative staff (22%). Two hundred and ninety participants (32.8%) had a positive-test result in any of the visits, yielding an overall adjusted prevalence of 33.5% for the whole study-period. Two hundred and thirty-five positive tests were identified at the baseline visit (prevalent cases), the remaining 55 positive tests were incident cases. Prevalent cases showed associations with both occupational (institution 2 vs. 1: adjusted odds ratio [aOR] = 2.24, 95% confidence interval [CI]: 1.54–3.25; laboratory technician vs. physician: aOR = 4.38, 95% CI: 1.75–10.93) and community (municipality of residence Xochimilco vs. Tlalpan: aOR = 2.03, 95% CI: 1.09–3.79) risk-factors. The incidence rate was 3.0 cases per 100 person-months. Incident cases were associated with community-acquired risk, due to contact with suspect/confirmed COVID-19 cases (HR = 2.45, 95% CI: 1.21–5.00). <h4>Conclusions</h4> We observed that between October 2020 and June 2021, healthcare workers of the two largest tertiary COVID-19 referral centers in Mexico City had similar level of exposure to SARS-CoV-2 than the general population. Most variables associated with exposure in this setting pointed toward community rather than occupational risk. Our observations are consistent with successful occupational medicine programs for SARS-CoV-2 infection control in the participating institutions but suggest the need to strengthen mitigation strategies in the community. |
| first_indexed | 2024-12-13T00:04:06Z |
| format | Article |
| id | doaj.art-268f05f9969e4378be208e02fa7141c1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T00:04:06Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-268f05f9969e4378be208e02fa7141c12022-12-22T00:06:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01173Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico CityVanessa Dávila-ConnMaribel Soto-NavaYanink N. Caro-VegaHéctor E. Paz-JuárezPedro García-EsparzaDaniela Tapia-TrejoMarissa Pérez-GarcíaPablo F. Belaunzarán-ZamudioGustavo Reyes-TeránJuan G. Sierra-MaderoArturo Galindo-FragaSantiago Ávila-Ríos<h4>Introduction</h4> We performed a longitudinal SARS-CoV-2 seroepidemiological study in healthcare personnel of the two largest tertiary COVID-19 referral hospitals in Mexico City. <h4>Methods</h4> All healthcare personnel, including staff physicians, physicians in training, nurses, laboratory technicians, researchers, students, housekeeping, maintenance, security, and administrative staff were invited to voluntarily participate, after written informed consent. Participants answered a computer-assisted self-administered interview and donated blood samples for antibody testing every three weeks from October 2020 to June 2021. <h4>Results</h4> A total of 883 participants (out of 3639 registered employees) contributed with at least one blood sample. The median age was 36 years (interquartile range: 28–46) and 70% were women. The most common occupations were nurse (28%), physician (24%), and administrative staff (22%). Two hundred and ninety participants (32.8%) had a positive-test result in any of the visits, yielding an overall adjusted prevalence of 33.5% for the whole study-period. Two hundred and thirty-five positive tests were identified at the baseline visit (prevalent cases), the remaining 55 positive tests were incident cases. Prevalent cases showed associations with both occupational (institution 2 vs. 1: adjusted odds ratio [aOR] = 2.24, 95% confidence interval [CI]: 1.54–3.25; laboratory technician vs. physician: aOR = 4.38, 95% CI: 1.75–10.93) and community (municipality of residence Xochimilco vs. Tlalpan: aOR = 2.03, 95% CI: 1.09–3.79) risk-factors. The incidence rate was 3.0 cases per 100 person-months. Incident cases were associated with community-acquired risk, due to contact with suspect/confirmed COVID-19 cases (HR = 2.45, 95% CI: 1.21–5.00). <h4>Conclusions</h4> We observed that between October 2020 and June 2021, healthcare workers of the two largest tertiary COVID-19 referral centers in Mexico City had similar level of exposure to SARS-CoV-2 than the general population. Most variables associated with exposure in this setting pointed toward community rather than occupational risk. Our observations are consistent with successful occupational medicine programs for SARS-CoV-2 infection control in the participating institutions but suggest the need to strengthen mitigation strategies in the community.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929624/?tool=EBI |
| spellingShingle | Vanessa Dávila-Conn Maribel Soto-Nava Yanink N. Caro-Vega Héctor E. Paz-Juárez Pedro García-Esparza Daniela Tapia-Trejo Marissa Pérez-García Pablo F. Belaunzarán-Zamudio Gustavo Reyes-Terán Juan G. Sierra-Madero Arturo Galindo-Fraga Santiago Ávila-Ríos Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City PLoS ONE |
| title | Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City |
| title_full | Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City |
| title_fullStr | Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City |
| title_full_unstemmed | Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City |
| title_short | Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City |
| title_sort | seroepidemiology of sars cov 2 in healthcare personnel working at the largest tertiary covid 19 referral hospitals in mexico city |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929624/?tool=EBI |
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