Evaluation of In Vitro Production of IFN-γ, IL-10, IL-12 and IL-13 by Blood Cells in Patients with Cutaneous Leishmaniasis Lesions
This study investigated the in vitro production of interferon-γ, interleukin (IL)-10, IL-12, and IL-13, after antigenic stimulation of the cells (with Leishmania antigen and lipopolysaccharide) using whole blood from patients with cutaneous leishmaniasis lesions caused by Leishmania tropica and in v...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2005-03-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/94 |
| _version_ | 1818655292640985088 |
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| author | Majid Mahmoodi Saeid Rajabalian Alireza Fekri Iraj Esfiarpour |
| author_facet | Majid Mahmoodi Saeid Rajabalian Alireza Fekri Iraj Esfiarpour |
| author_sort | Majid Mahmoodi |
| collection | DOAJ |
| description | This study investigated the in vitro production of interferon-γ, interleukin (IL)-10, IL-12, and IL-13, after antigenic stimulation of the cells (with Leishmania antigen and lipopolysaccharide) using whole blood from patients with cutaneous leishmaniasis lesions caused by Leishmania tropica and in volunteers with history of cutaneous leishmaniasis.
ELISA results showed that the mean production of interferon-γ by cells of whole blood in patients with lesions in response to Leishmania antigen was significantly lower than corresponding values in volunteers with history of cutaneous leishmaniasis (P< 0.05) and significantly higher levels of IL-10 production in patients with lesions were observed compared with cured volunteers of the disease (P |
| first_indexed | 2024-12-17T03:07:22Z |
| format | Article |
| id | doaj.art-268f20b811254f82ae230540fe7f4f74 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-17T03:07:22Z |
| publishDate | 2005-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-268f20b811254f82ae230540fe7f4f742022-12-21T22:05:55ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492005-03-014194Evaluation of In Vitro Production of IFN-γ, IL-10, IL-12 and IL-13 by Blood Cells in Patients with Cutaneous Leishmaniasis Lesions Majid Mahmoodi0 Saeid Rajabalian1 Alireza Fekri2 Iraj Esfiarpour3 This study investigated the in vitro production of interferon-γ, interleukin (IL)-10, IL-12, and IL-13, after antigenic stimulation of the cells (with Leishmania antigen and lipopolysaccharide) using whole blood from patients with cutaneous leishmaniasis lesions caused by Leishmania tropica and in volunteers with history of cutaneous leishmaniasis. ELISA results showed that the mean production of interferon-γ by cells of whole blood in patients with lesions in response to Leishmania antigen was significantly lower than corresponding values in volunteers with history of cutaneous leishmaniasis (P< 0.05) and significantly higher levels of IL-10 production in patients with lesions were observed compared with cured volunteers of the disease (Phttps://ijaai.tums.ac.ir/index.php/ijaai/article/view/94Interferon-γInterleukinIL5IL10IL12IL13 |
| spellingShingle | Majid Mahmoodi Saeid Rajabalian Alireza Fekri Iraj Esfiarpour Evaluation of In Vitro Production of IFN-γ, IL-10, IL-12 and IL-13 by Blood Cells in Patients with Cutaneous Leishmaniasis Lesions Iranian Journal of Allergy, Asthma and Immunology Interferon-γ Interleukin IL5 IL10 IL12 IL13 |
| title | Evaluation of In Vitro Production of IFN-γ, IL-10, IL-12 and IL-13 by Blood Cells in Patients with Cutaneous Leishmaniasis Lesions |
| title_full | Evaluation of In Vitro Production of IFN-γ, IL-10, IL-12 and IL-13 by Blood Cells in Patients with Cutaneous Leishmaniasis Lesions |
| title_fullStr | Evaluation of In Vitro Production of IFN-γ, IL-10, IL-12 and IL-13 by Blood Cells in Patients with Cutaneous Leishmaniasis Lesions |
| title_full_unstemmed | Evaluation of In Vitro Production of IFN-γ, IL-10, IL-12 and IL-13 by Blood Cells in Patients with Cutaneous Leishmaniasis Lesions |
| title_short | Evaluation of In Vitro Production of IFN-γ, IL-10, IL-12 and IL-13 by Blood Cells in Patients with Cutaneous Leishmaniasis Lesions |
| title_sort | evaluation of in vitro production of ifn γ il 10 il 12 and il 13 by blood cells in patients with cutaneous leishmaniasis lesions |
| topic | Interferon-γ Interleukin IL5 IL10 IL12 IL13 |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/94 |
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