Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review
Stroke is the leading cause of global mortality and disability. Cerebral edema and intracranial hypertension are common complications of cerebral infarction and the major causes of mortality. The formation of cerebral edema includes three stages (cytotoxic edema, ionic edema, and vasogenic edema), w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2020.618819/full |
| _version_ | 1819180872698429440 |
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| author | Yi Yao Yonggang Zhang Yonggang Zhang Yonggang Zhang Xiaoyang Liao Rong Yang Yi Lei Jianzhao Luo |
| author_facet | Yi Yao Yonggang Zhang Yonggang Zhang Yonggang Zhang Xiaoyang Liao Rong Yang Yi Lei Jianzhao Luo |
| author_sort | Yi Yao |
| collection | DOAJ |
| description | Stroke is the leading cause of global mortality and disability. Cerebral edema and intracranial hypertension are common complications of cerebral infarction and the major causes of mortality. The formation of cerebral edema includes three stages (cytotoxic edema, ionic edema, and vasogenic edema), which involve multiple proteins and ion channels. A range of therapeutic agents that successfully target cerebral edema have been developed in animal studies, some of which have been assessed in clinical trials. Herein, we review the mechanisms of cerebral edema and the research progress of anti-edema therapies for use after ischemic stroke. |
| first_indexed | 2024-12-22T22:21:15Z |
| format | Article |
| id | doaj.art-2692920309fc4155b4f1655d157240ef |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-22T22:21:15Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-2692920309fc4155b4f1655d157240ef2022-12-21T18:10:39ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-02-011210.3389/fnagi.2020.618819618819Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini ReviewYi Yao0Yonggang Zhang1Yonggang Zhang2Yonggang Zhang3Xiaoyang Liao4Rong Yang5Yi Lei6Jianzhao Luo7International Medical Center, Ward of General Practice and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Periodical Press and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaNursing Key Laboratory of Sichuan Province, Chengdu, ChinaChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, ChinaInternational Medical Center, Ward of General Practice and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaInternational Medical Center, Ward of General Practice and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaInternational Medical Center, Ward of General Practice and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaInternational Medical Center, Ward of General Practice and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaStroke is the leading cause of global mortality and disability. Cerebral edema and intracranial hypertension are common complications of cerebral infarction and the major causes of mortality. The formation of cerebral edema includes three stages (cytotoxic edema, ionic edema, and vasogenic edema), which involve multiple proteins and ion channels. A range of therapeutic agents that successfully target cerebral edema have been developed in animal studies, some of which have been assessed in clinical trials. Herein, we review the mechanisms of cerebral edema and the research progress of anti-edema therapies for use after ischemic stroke.https://www.frontiersin.org/articles/10.3389/fnagi.2020.618819/fullischemia strokecerebral edemamolecular mechanismdrug therapypreclinical drug evaluationclinical trial |
| spellingShingle | Yi Yao Yonggang Zhang Yonggang Zhang Yonggang Zhang Xiaoyang Liao Rong Yang Yi Lei Jianzhao Luo Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review Frontiers in Aging Neuroscience ischemia stroke cerebral edema molecular mechanism drug therapy preclinical drug evaluation clinical trial |
| title | Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review |
| title_full | Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review |
| title_fullStr | Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review |
| title_full_unstemmed | Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review |
| title_short | Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review |
| title_sort | potential therapies for cerebral edema after ischemic stroke a mini review |
| topic | ischemia stroke cerebral edema molecular mechanism drug therapy preclinical drug evaluation clinical trial |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2020.618819/full |
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