Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease
Altered Ca2+ signaling is involved in the pathogenesis of Alzheimer’s disease. Here, the authors show Ca2+ hypoactivity in astrocytes at plaque deposition onset related to reduced expression of the Ca2+ sensor STIM1 and impaired synaptic plasticity that was rescued by STIM1 overexpression in astrocy...
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Bibliographic Details
| Main Authors: |
Annamaria Lia,
Gabriele Sansevero,
Angela Chiavegato,
Miriana Sbrissa,
Diana Pendin,
Letizia Mariotti,
Tullio Pozzan,
Nicoletta Berardi,
Giorgio Carmignoto,
Cristina Fasolato,
Micaela Zonta |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-023-37240-2
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