Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease
Altered Ca2+ signaling is involved in the pathogenesis of Alzheimer’s disease. Here, the authors show Ca2+ hypoactivity in astrocytes at plaque deposition onset related to reduced expression of the Ca2+ sensor STIM1 and impaired synaptic plasticity that was rescued by STIM1 overexpression in astrocy...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37240-2 |
| _version_ | 1797859869467869184 |
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| author | Annamaria Lia Gabriele Sansevero Angela Chiavegato Miriana Sbrissa Diana Pendin Letizia Mariotti Tullio Pozzan Nicoletta Berardi Giorgio Carmignoto Cristina Fasolato Micaela Zonta |
| author_facet | Annamaria Lia Gabriele Sansevero Angela Chiavegato Miriana Sbrissa Diana Pendin Letizia Mariotti Tullio Pozzan Nicoletta Berardi Giorgio Carmignoto Cristina Fasolato Micaela Zonta |
| author_sort | Annamaria Lia |
| collection | DOAJ |
| description | Altered Ca2+ signaling is involved in the pathogenesis of Alzheimer’s disease. Here, the authors show Ca2+ hypoactivity in astrocytes at plaque deposition onset related to reduced expression of the Ca2+ sensor STIM1 and impaired synaptic plasticity that was rescued by STIM1 overexpression in astrocytes. |
| first_indexed | 2024-04-09T21:36:32Z |
| format | Article |
| id | doaj.art-2692d4385d9d452f9a4c2132e63f0f7d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T21:36:32Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2692d4385d9d452f9a4c2132e63f0f7d2023-03-26T11:13:26ZengNature PortfolioNature Communications2041-17232023-03-0114111510.1038/s41467-023-37240-2Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s diseaseAnnamaria Lia0Gabriele Sansevero1Angela Chiavegato2Miriana Sbrissa3Diana Pendin4Letizia Mariotti5Tullio Pozzan6Nicoletta Berardi7Giorgio Carmignoto8Cristina Fasolato9Micaela Zonta10Neuroscience Institute, National Research Council (CNR)Neuroscience Institute, National Research Council (CNR)Department of Biomedical Sciences, University of PaduaDepartment of Biomedical Sciences, University of PaduaNeuroscience Institute, National Research Council (CNR)Neuroscience Institute, National Research Council (CNR)Neuroscience Institute, National Research Council (CNR)Neuroscience Institute, National Research Council (CNR)Neuroscience Institute, National Research Council (CNR)Department of Biomedical Sciences, University of PaduaNeuroscience Institute, National Research Council (CNR)Altered Ca2+ signaling is involved in the pathogenesis of Alzheimer’s disease. Here, the authors show Ca2+ hypoactivity in astrocytes at plaque deposition onset related to reduced expression of the Ca2+ sensor STIM1 and impaired synaptic plasticity that was rescued by STIM1 overexpression in astrocytes.https://doi.org/10.1038/s41467-023-37240-2 |
| spellingShingle | Annamaria Lia Gabriele Sansevero Angela Chiavegato Miriana Sbrissa Diana Pendin Letizia Mariotti Tullio Pozzan Nicoletta Berardi Giorgio Carmignoto Cristina Fasolato Micaela Zonta Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease Nature Communications |
| title | Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease |
| title_full | Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease |
| title_fullStr | Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease |
| title_full_unstemmed | Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease |
| title_short | Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease |
| title_sort | rescue of astrocyte activity by the calcium sensor stim1 restores long term synaptic plasticity in female mice modelling alzheimer s disease |
| url | https://doi.org/10.1038/s41467-023-37240-2 |
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