The Comparison of Two Types of Treatment (High Dose and Low Dose IVIG) in Children with GBS in Mofid Hospital
Objective: Acute inflammatory demyelinating peripheral neuropathy (Guillain-Barre-Syndrome) is by far the most common cause of immune–mediated peripheral nerve disease in children and with the near disappearance of poliomyelitis, is responsible for the great majority of cases of acute flaccid paraly...
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| Format: | Article |
| Language: | fas |
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University of Social Welfare and Rehabilitation Sciences
2003-12-01
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| Series: | Journal of Rehabilitation |
| Subjects: | |
| Online Access: | http://rehabilitationj.uswr.ac.ir/browse.php?a_code=A-10-1-2&slc_lang=en&sid=1 |
| _version_ | 1819050665546088448 |
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| author | Parvaneh Karim-Zadeh Mohammad Ghofrani |
| author_facet | Parvaneh Karim-Zadeh Mohammad Ghofrani |
| author_sort | Parvaneh Karim-Zadeh |
| collection | DOAJ |
| description | Objective: Acute inflammatory demyelinating peripheral neuropathy (Guillain-Barre-Syndrome) is by far the most common cause of immune–mediated peripheral nerve disease in children and with the near disappearance of poliomyelitis, is responsible for the great majority of cases of acute flaccid paralysis. Several controlled studies have done with corticosteroids, plasma pheresis and IVIG in pediatric patients. IVIG treatment can be done in two types of treatment:
1- High dose that means 1gr/kg/day for 2 days.
2- Low dose that means 400mg/kg/day for 5 days.
Several studies in other countries have shown faster rate of recovery in patients who received total dose of IVIG in 2 days as opposed to 5 days.
Materials & Methods: Because we have not any study about this two types of treatment in IRAN we decided to comparison this two types of IVIG treatment. So the patients that referred to Mofid children hospital for weakness and we diagnosed GBS (with history, physical examination, laboratories and EMG-NCV) are divided in two groups: 1- High dose IVIG treatment (experimental group). 2- Low dose IVIG treatment (control group) Then the results evaluated.
Results: Our findings included that in high dose IVIG therapy we have faster rate of recovery and the Hospital stay is shorter than low dose IVIG-therapy. Also in this type of treatment “because the patients cure faster” , so complications are decreased in them. In the group of high dose IVIG therapy, lower and upper extremities weakness decreased in time.
Conclusion: We did not receive any relationship between side effects of drugs and the type of treatment. The relationship between high dose IVIG therapy and drug side effects was not significant. |
| first_indexed | 2024-12-21T11:51:39Z |
| format | Article |
| id | doaj.art-2693d712ef5345e7b343d67643ae3b37 |
| institution | Directory Open Access Journal |
| issn | 1607-2960 1607-2960 |
| language | fas |
| last_indexed | 2024-12-21T11:51:39Z |
| publishDate | 2003-12-01 |
| publisher | University of Social Welfare and Rehabilitation Sciences |
| record_format | Article |
| series | Journal of Rehabilitation |
| spelling | doaj.art-2693d712ef5345e7b343d67643ae3b372022-12-21T19:05:02ZfasUniversity of Social Welfare and Rehabilitation SciencesJournal of Rehabilitation1607-29601607-29602003-12-0143712The Comparison of Two Types of Treatment (High Dose and Low Dose IVIG) in Children with GBS in Mofid HospitalParvaneh Karim-Zadeh0Mohammad Ghofrani1 University of Welfare and Rehabilitation Sciences, Tehran, Iran. Objective: Acute inflammatory demyelinating peripheral neuropathy (Guillain-Barre-Syndrome) is by far the most common cause of immune–mediated peripheral nerve disease in children and with the near disappearance of poliomyelitis, is responsible for the great majority of cases of acute flaccid paralysis. Several controlled studies have done with corticosteroids, plasma pheresis and IVIG in pediatric patients. IVIG treatment can be done in two types of treatment: 1- High dose that means 1gr/kg/day for 2 days. 2- Low dose that means 400mg/kg/day for 5 days. Several studies in other countries have shown faster rate of recovery in patients who received total dose of IVIG in 2 days as opposed to 5 days. Materials & Methods: Because we have not any study about this two types of treatment in IRAN we decided to comparison this two types of IVIG treatment. So the patients that referred to Mofid children hospital for weakness and we diagnosed GBS (with history, physical examination, laboratories and EMG-NCV) are divided in two groups: 1- High dose IVIG treatment (experimental group). 2- Low dose IVIG treatment (control group) Then the results evaluated. Results: Our findings included that in high dose IVIG therapy we have faster rate of recovery and the Hospital stay is shorter than low dose IVIG-therapy. Also in this type of treatment “because the patients cure faster” , so complications are decreased in them. In the group of high dose IVIG therapy, lower and upper extremities weakness decreased in time. Conclusion: We did not receive any relationship between side effects of drugs and the type of treatment. The relationship between high dose IVIG therapy and drug side effects was not significant.http://rehabilitationj.uswr.ac.ir/browse.php?a_code=A-10-1-2&slc_lang=en&sid=1Gilliain barre syndrome-high dose Low dose IVIG-comparison-son of two types of treatment |
| spellingShingle | Parvaneh Karim-Zadeh Mohammad Ghofrani The Comparison of Two Types of Treatment (High Dose and Low Dose IVIG) in Children with GBS in Mofid Hospital Journal of Rehabilitation Gilliain barre syndrome-high dose Low dose IVIG-comparison-son of two types of treatment |
| title | The Comparison of Two Types of Treatment (High Dose and Low Dose IVIG) in Children with GBS in Mofid Hospital |
| title_full | The Comparison of Two Types of Treatment (High Dose and Low Dose IVIG) in Children with GBS in Mofid Hospital |
| title_fullStr | The Comparison of Two Types of Treatment (High Dose and Low Dose IVIG) in Children with GBS in Mofid Hospital |
| title_full_unstemmed | The Comparison of Two Types of Treatment (High Dose and Low Dose IVIG) in Children with GBS in Mofid Hospital |
| title_short | The Comparison of Two Types of Treatment (High Dose and Low Dose IVIG) in Children with GBS in Mofid Hospital |
| title_sort | comparison of two types of treatment high dose and low dose ivig in children with gbs in mofid hospital |
| topic | Gilliain barre syndrome-high dose Low dose IVIG-comparison-son of two types of treatment |
| url | http://rehabilitationj.uswr.ac.ir/browse.php?a_code=A-10-1-2&slc_lang=en&sid=1 |
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