Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Study
Myosteatosis is a complex condition, associated with aging and diverse pathological conditions (e.g., diabetes), that contributes to mobility disability. Improved characterization of myosteatosis is required to develop targeted interventions to maintain muscle health in aging. We first determined th...
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MDPI AG
2021-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/4/224 |
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| author | Samaneh Farsijani Megan M. Marron Iva Miljkovic Mary Elizabeth Baugh Stephen B. Kritchevsky Anne B. Newman |
| author_facet | Samaneh Farsijani Megan M. Marron Iva Miljkovic Mary Elizabeth Baugh Stephen B. Kritchevsky Anne B. Newman |
| author_sort | Samaneh Farsijani |
| collection | DOAJ |
| description | Myosteatosis is a complex condition, associated with aging and diverse pathological conditions (e.g., diabetes), that contributes to mobility disability. Improved characterization of myosteatosis is required to develop targeted interventions to maintain muscle health in aging. We first determined the associations between plasma metabolites and intermuscular fat (IMF) in a cross-sectional analysis of 313 older Black men from Health ABC Study. Using partial correlation analysis, 34/350 metabolites were associated with IMF, the majority of which were lipids and organic acids. Next, we used Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), as an indicator of metabolic health to delineate the anthropometric, functional, and metabolic heterogeneity of myosteatosis in a case-control matching analysis. We categorized participants based on their IMF and HOMA-IR levels into: Low-IMF with Low- versus High-HOMA, as well as High-IMF with Low- versus High-HOMA. Among participants with similar levels of IMF, those who were metabolically unhealthy, i.e., with High HOMA-IR, had higher fat and lean mass, muscle strength, and had hyperglycemia, hypertriglyceridemia, hyperinsulinemia, and higher levels of plasma metabolites belonging to diacylglycerols, triacylglycerols, fatty acid and aminoacyl-tRNA biosynthesis pathways versus those with Low HOMA-IR. In summary, HOMA-IR delineates the heterogeneity of myosteatosis by distinguishing metabolically healthy versus unhealthy individuals. |
| first_indexed | 2024-03-10T12:32:38Z |
| format | Article |
| id | doaj.art-2694a3a859a14dfe8de1678b006da125 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T12:32:38Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-2694a3a859a14dfe8de1678b006da1252023-11-21T14:29:36ZengMDPI AGMetabolites2218-19892021-04-0111422410.3390/metabo11040224Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC StudySamaneh Farsijani0Megan M. Marron1Iva Miljkovic2Mary Elizabeth Baugh3Stephen B. Kritchevsky4Anne B. Newman5Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USAFralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, VA 24016, USASection on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USAMyosteatosis is a complex condition, associated with aging and diverse pathological conditions (e.g., diabetes), that contributes to mobility disability. Improved characterization of myosteatosis is required to develop targeted interventions to maintain muscle health in aging. We first determined the associations between plasma metabolites and intermuscular fat (IMF) in a cross-sectional analysis of 313 older Black men from Health ABC Study. Using partial correlation analysis, 34/350 metabolites were associated with IMF, the majority of which were lipids and organic acids. Next, we used Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), as an indicator of metabolic health to delineate the anthropometric, functional, and metabolic heterogeneity of myosteatosis in a case-control matching analysis. We categorized participants based on their IMF and HOMA-IR levels into: Low-IMF with Low- versus High-HOMA, as well as High-IMF with Low- versus High-HOMA. Among participants with similar levels of IMF, those who were metabolically unhealthy, i.e., with High HOMA-IR, had higher fat and lean mass, muscle strength, and had hyperglycemia, hypertriglyceridemia, hyperinsulinemia, and higher levels of plasma metabolites belonging to diacylglycerols, triacylglycerols, fatty acid and aminoacyl-tRNA biosynthesis pathways versus those with Low HOMA-IR. In summary, HOMA-IR delineates the heterogeneity of myosteatosis by distinguishing metabolically healthy versus unhealthy individuals.https://www.mdpi.com/2218-1989/11/4/224myosteatosismetabolomicsagingheterogeneityAfrican Americanmobility |
| spellingShingle | Samaneh Farsijani Megan M. Marron Iva Miljkovic Mary Elizabeth Baugh Stephen B. Kritchevsky Anne B. Newman Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Study Metabolites myosteatosis metabolomics aging heterogeneity African American mobility |
| title | Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Study |
| title_full | Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Study |
| title_fullStr | Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Study |
| title_full_unstemmed | Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Study |
| title_short | Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Study |
| title_sort | metabolic markers demonstrate the heterogeneity of myosteatosis in community dwelling older black men from the health abc study |
| topic | myosteatosis metabolomics aging heterogeneity African American mobility |
| url | https://www.mdpi.com/2218-1989/11/4/224 |
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