Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation
Purpose This study aimed to evaluate the usefulness of two-dimensional shear wave elastography (2D-SWE) in diagnosing hepatic veno-occlusive disease (VOD) in pediatric patients. Methods This study retrospectively included pediatric patients who underwent hematopoietic stem cell transplantation (HSCT...
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| Format: | Article |
| Language: | English |
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Korean Society of Ultrasound in Medicine
2023-04-01
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| Series: | Ultrasonography |
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| Online Access: | http://www.e-ultrasonography.org/upload/usg-22107.pdf |
| _version_ | 1797853435951841280 |
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| author | Yoon Seong Lee Seunghyun Lee Young Hun Choi Yeon Jin Cho Seul Bi Lee Jung-Eun Cheon Kyung Taek Hong Hyoung Jin Kang |
| author_facet | Yoon Seong Lee Seunghyun Lee Young Hun Choi Yeon Jin Cho Seul Bi Lee Jung-Eun Cheon Kyung Taek Hong Hyoung Jin Kang |
| author_sort | Yoon Seong Lee |
| collection | DOAJ |
| description | Purpose This study aimed to evaluate the usefulness of two-dimensional shear wave elastography (2D-SWE) in diagnosing hepatic veno-occlusive disease (VOD) in pediatric patients. Methods This study retrospectively included pediatric patients who underwent hematopoietic stem cell transplantation (HSCT) between November 2019 and January 2021. All 34 patients (8.7±5.0 years) were examined using 2D-SWE for an initial diagnosis. A subgroup analysis was performed using the data from follow-up examinations of patients diagnosed with VOD. The characteristics of the initial VOD diagnosis were compared with the longitudinal changes observed in VOD patients who underwent multiple ultrasound examinations. Results In total, 19 patients were diagnosed with VOD at 17.6±9.4 days after HSCT. All VOD patients showed hepatomegaly, ascites, and gallbladder wall thickening. Liver stiffness was higher in VOD patients than in non-VOD patients (12.4±1.1 vs. 6.3±0.8 kPa, P<0.001). Liver stiffness values above 7.2 kPa showed 84.2% sensitivity and 93.3% specificity in distinguishing VOD from non-VOD (area under the curve, 0.925; 95% confidence interval, 0.780 to 0.987; P<0.001). A subgroup analysis of 11 patients showed a linear decrease in liver stiffness values after VOD diagnosis with treatment (first, second, and third follow-ups; 13.5±1.7, 11.3±1.4, and 9.5±0.8 kPa, respectively), but without statistical significance in the pairwise analysis. Conclusion Liver stiffness measured using 2D-SWE increased in pediatric patients who develop VOD after HSCT. Therefore, liver stiffness can be a predictive and quantitative parameter for diagnosing VOD. |
| first_indexed | 2024-04-09T19:50:36Z |
| format | Article |
| id | doaj.art-269648d6197243a78a6acd309c8979ef |
| institution | Directory Open Access Journal |
| issn | 2288-5943 |
| language | English |
| last_indexed | 2024-04-09T19:50:36Z |
| publishDate | 2023-04-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-269648d6197243a78a6acd309c8979ef2023-04-03T06:45:11ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59432023-04-0142228629610.14366/usg.221071654Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantationYoon Seong Lee0Seunghyun Lee1Young Hun Choi2Yeon Jin Cho3Seul Bi Lee4Jung-Eun Cheon5Kyung Taek Hong6Hyoung Jin Kang7 Department of Radiology, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University Hospital, Seoul, Korea Department of Pediatrics, Seoul National University Hospital, Seoul, Korea Department of Pediatrics, Seoul National University Hospital, Seoul, KoreaPurpose This study aimed to evaluate the usefulness of two-dimensional shear wave elastography (2D-SWE) in diagnosing hepatic veno-occlusive disease (VOD) in pediatric patients. Methods This study retrospectively included pediatric patients who underwent hematopoietic stem cell transplantation (HSCT) between November 2019 and January 2021. All 34 patients (8.7±5.0 years) were examined using 2D-SWE for an initial diagnosis. A subgroup analysis was performed using the data from follow-up examinations of patients diagnosed with VOD. The characteristics of the initial VOD diagnosis were compared with the longitudinal changes observed in VOD patients who underwent multiple ultrasound examinations. Results In total, 19 patients were diagnosed with VOD at 17.6±9.4 days after HSCT. All VOD patients showed hepatomegaly, ascites, and gallbladder wall thickening. Liver stiffness was higher in VOD patients than in non-VOD patients (12.4±1.1 vs. 6.3±0.8 kPa, P<0.001). Liver stiffness values above 7.2 kPa showed 84.2% sensitivity and 93.3% specificity in distinguishing VOD from non-VOD (area under the curve, 0.925; 95% confidence interval, 0.780 to 0.987; P<0.001). A subgroup analysis of 11 patients showed a linear decrease in liver stiffness values after VOD diagnosis with treatment (first, second, and third follow-ups; 13.5±1.7, 11.3±1.4, and 9.5±0.8 kPa, respectively), but without statistical significance in the pairwise analysis. Conclusion Liver stiffness measured using 2D-SWE increased in pediatric patients who develop VOD after HSCT. Therefore, liver stiffness can be a predictive and quantitative parameter for diagnosing VOD.http://www.e-ultrasonography.org/upload/usg-22107.pdfpediatricshepatic veno-occlusive diseaseelasticity imaging techniquesultrasonographyhematopoietic stem cell transplantation |
| spellingShingle | Yoon Seong Lee Seunghyun Lee Young Hun Choi Yeon Jin Cho Seul Bi Lee Jung-Eun Cheon Kyung Taek Hong Hyoung Jin Kang Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation Ultrasonography pediatrics hepatic veno-occlusive disease elasticity imaging techniques ultrasonography hematopoietic stem cell transplantation |
| title | Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation |
| title_full | Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation |
| title_fullStr | Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation |
| title_full_unstemmed | Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation |
| title_short | Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation |
| title_sort | usefulness of two dimensional shear wave elastography in diagnosing hepatic veno occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation |
| topic | pediatrics hepatic veno-occlusive disease elasticity imaging techniques ultrasonography hematopoietic stem cell transplantation |
| url | http://www.e-ultrasonography.org/upload/usg-22107.pdf |
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