Cranial Neural Crest Specific Deletion of <i>Alpl</i> (TNAP) via P0-Cre Causes Abnormal Chondrocyte Maturation and Deficient Cranial Base Growth

Cranial Neural Crest Specific Deletion of <i>Alpl</i> (TNAP) via P0-Cre Causes Abnormal Chondrocyte Maturation and Deficient Cranial Base Growth

Bone growth plate abnormalities and skull shape defects are seen in hypophosphatasia, a heritable disorder in humans that occurs due to the deficiency of tissue nonspecific alkaline phosphatase (TNAP, <i>Alpl</i>) enzyme activity. The abnormal development of the cranial base growth plate...

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Bibliographic Details
Main Authors: Naoto Ohkura, Hwa Kyung Nam, Fei Liu, Nan Hatch
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
tissue nonspecific alkaline phosphatase
hypophosphatasia
cranial neural crest
cranial base
synchondrosis
chondrocyte
Online Access:https://www.mdpi.com/1422-0067/24/20/15401

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