Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder
Anomalies in large-scale cognitive control networks impacting social attention abilities are hypothesized to be the cause of attention deficit hyperactivity disorder (ADHD). The precise nature of abnormal brain functional connectivity (FC) dynamics including other regions, on the other hand, is unkn...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.890596/full |
| _version_ | 1818469241411600384 |
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| author | Ahmed Ameen Fateh Wenxian Huang Tong Mo Xiaoyu Wang Yi Luo Binrang Yang Abla Smahi Diangang Fang Linlin Zhang Xianlei Meng Hongwu Zeng |
| author_facet | Ahmed Ameen Fateh Wenxian Huang Tong Mo Xiaoyu Wang Yi Luo Binrang Yang Abla Smahi Diangang Fang Linlin Zhang Xianlei Meng Hongwu Zeng |
| author_sort | Ahmed Ameen Fateh |
| collection | DOAJ |
| description | Anomalies in large-scale cognitive control networks impacting social attention abilities are hypothesized to be the cause of attention deficit hyperactivity disorder (ADHD). The precise nature of abnormal brain functional connectivity (FC) dynamics including other regions, on the other hand, is unknown. The concept that insular dynamic FC (dFC) among distinct brain regions is dysregulated in children with ADHD was evaluated using Insular subregions, and we studied how these dysregulations lead to social dysfunctioning. Data from 30 children with ADHD and 28 healthy controls (HCs) were evaluated using dynamic resting state functional magnetic resonance imaging (rs-fMRI). We evaluated the dFC within six subdivisions, namely both left and right dorsal anterior insula (dAI), ventral anterior insula (vAI), and posterior insula (PI). Using the insular sub-regions as seeds, we performed group comparison between the two groups. To do so, two sample t-tests were used, followed by post-hoc t-tests. Compared to the HCs, patients with ADHD exhibited decreased dFC values between right dAI and the left middle frontal gyrus, left postcentral gyrus and right of cerebellum crus, respectively. Results also showed a decreased dFC between left dAI and thalamus, left vAI and left precuneus and left PI with temporal pole. From the standpoint of the dynamic functional connectivity of insular subregions, our findings add to the growing body of evidence on brain dysfunction in ADHD. This research adds to our understanding of the neurocognitive mechanisms behind social functioning deficits in ADHD. Future ADHD research could benefit from merging the dFC approach with task-related fMRI and non-invasive brain stimulation, which could aid in the diagnosis and treatment of the disorder. |
| first_indexed | 2024-04-13T21:21:25Z |
| format | Article |
| id | doaj.art-269967d8081f4f0fb63a4f3518741d53 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T21:21:25Z |
| publishDate | 2022-05-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-269967d8081f4f0fb63a4f3518741d532022-12-22T02:29:29ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-05-011610.3389/fnins.2022.890596890596Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity DisorderAhmed Ameen Fateh0Wenxian Huang1Tong Mo2Xiaoyu Wang3Yi Luo4Binrang Yang5Abla Smahi6Diangang Fang7Linlin Zhang8Xianlei Meng9Hongwu Zeng10Department of Radiology, Shenzhen Children's Hospital, Shenzhen, ChinaChildren's Healthcare, Mental Health Center, Shenzhen Children's Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, ChinaChildren's Healthcare, Mental Health Center, Shenzhen Children's Hospital, Shenzhen, ChinaShenzhen Graduate School, Peking University, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, ChinaChildren's Healthcare, Mental Health Center, Shenzhen Children's Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, ChinaAnomalies in large-scale cognitive control networks impacting social attention abilities are hypothesized to be the cause of attention deficit hyperactivity disorder (ADHD). The precise nature of abnormal brain functional connectivity (FC) dynamics including other regions, on the other hand, is unknown. The concept that insular dynamic FC (dFC) among distinct brain regions is dysregulated in children with ADHD was evaluated using Insular subregions, and we studied how these dysregulations lead to social dysfunctioning. Data from 30 children with ADHD and 28 healthy controls (HCs) were evaluated using dynamic resting state functional magnetic resonance imaging (rs-fMRI). We evaluated the dFC within six subdivisions, namely both left and right dorsal anterior insula (dAI), ventral anterior insula (vAI), and posterior insula (PI). Using the insular sub-regions as seeds, we performed group comparison between the two groups. To do so, two sample t-tests were used, followed by post-hoc t-tests. Compared to the HCs, patients with ADHD exhibited decreased dFC values between right dAI and the left middle frontal gyrus, left postcentral gyrus and right of cerebellum crus, respectively. Results also showed a decreased dFC between left dAI and thalamus, left vAI and left precuneus and left PI with temporal pole. From the standpoint of the dynamic functional connectivity of insular subregions, our findings add to the growing body of evidence on brain dysfunction in ADHD. This research adds to our understanding of the neurocognitive mechanisms behind social functioning deficits in ADHD. Future ADHD research could benefit from merging the dFC approach with task-related fMRI and non-invasive brain stimulation, which could aid in the diagnosis and treatment of the disorder.https://www.frontiersin.org/articles/10.3389/fnins.2022.890596/fullattention deficit hyperactivity disorderdynamic functional connectivityinsulars-fMRIsocial dysfunction |
| spellingShingle | Ahmed Ameen Fateh Wenxian Huang Tong Mo Xiaoyu Wang Yi Luo Binrang Yang Abla Smahi Diangang Fang Linlin Zhang Xianlei Meng Hongwu Zeng Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder Frontiers in Neuroscience attention deficit hyperactivity disorder dynamic functional connectivity insula rs-fMRI social dysfunction |
| title | Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder |
| title_full | Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder |
| title_fullStr | Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder |
| title_full_unstemmed | Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder |
| title_short | Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder |
| title_sort | abnormal insular dynamic functional connectivity and its relation to social dysfunctioning in children with attention deficit hyperactivity disorder |
| topic | attention deficit hyperactivity disorder dynamic functional connectivity insula rs-fMRI social dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.890596/full |
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