Pharmacogenetic profiles of young danish individuals with and without severe mental disorders
Introduction Pharmacogenetics (PGx) studies genetic variance and related differences in drug outcomes. PGx guidelines for psychotropic drugs are available (PGx drugs). By executing PGx testing in a prospective or pre-emptive setting, dose adjustments or even change of treatment type can be applied...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821003965/type/journal_article |
| _version_ | 1797617625852805120 |
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| author | C. Lunenburg J. Thirstrup C. Gasse |
| author_facet | C. Lunenburg J. Thirstrup C. Gasse |
| author_sort | C. Lunenburg |
| collection | DOAJ |
| description |
Introduction
Pharmacogenetics (PGx) studies genetic variance and related differences in drug outcomes. PGx guidelines for psychotropic drugs are available (PGx drugs). By executing PGx testing in a prospective or pre-emptive setting, dose adjustments or even change of treatment type can be applied prior to start of therapy to patients who carry a specific geno- or phenotype (i.e. actionable geno- or phenotypes). By doing so, increased efficacy of therapy or reduced risk of adverse events of treatment can be accomplished. In Denmark, broad implementation of PGx is currently still low.
Objectives
The aim of this study is to classify the PGx profiles of Danish individuals with and without severe mental disorders (SMD), to be used in follow-up studies investigating PGx and drug outcomes.
Methods
This study made use of imputed genotyping data of the Danish iPSYCH sample, which includes 77,639 young individuals born between 1981-2005, with or without a diagnosis of one or more of five selected SMD (i.e. depression, attention-deficit/hyperactivity disorder, autism, bipolar disorder and schizophrenia). We investigated a panel of 48 genetic variants with known PGx applications (part of the U-PGx consortium, a Horizon2020 funded project on clinical relevant PGx in the EU).
Results
Imputed data contains over 11 million SNPs of 77,639 individuals.
Conclusions
We expect results in the end of 2020.
Disclosure
We thank the iPSYCH consortium, in specific the iPSYCH PI’s (Merete Nordentoft, Anders Børglum, Preben B. Mortensen, Ole Mors, Thomas Werge and David M. Hougaard). The iPSYCH project is funded by the Lundbeck Foundation Denmark and the universities and un
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| first_indexed | 2024-03-11T07:58:30Z |
| format | Article |
| id | doaj.art-2699e778c51a4cebab3b791fe8f4122c |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:58:30Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-2699e778c51a4cebab3b791fe8f4122c2023-11-17T05:05:11ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S144S14510.1192/j.eurpsy.2021.396Pharmacogenetic profiles of young danish individuals with and without severe mental disordersC. Lunenburg0J. Thirstrup1C. Gasse2Department Of Clinical Medicine, Aarhus University, Aarhus, Denmark Dep. Affective Disorders, Aarhus University Hospital Psychiatry, Aarhus N, DenmarkDepartment Of Biomedicine, Faculty of Health, Aarhus University, Aarhus, DenmarkDepartment Of Clinical Medicine, Aarhus University, Aarhus, Denmark Dep. Affective Disorders, Aarhus University Hospital Psychiatry, Aarhus N, Denmark Psychosis Research Unit, Aarhus University Hospital Psychiatry, Aarhus N, Denmark Centre For Integrated Register-based Research, Aarhus University, Aarhus, Denmark Introduction Pharmacogenetics (PGx) studies genetic variance and related differences in drug outcomes. PGx guidelines for psychotropic drugs are available (PGx drugs). By executing PGx testing in a prospective or pre-emptive setting, dose adjustments or even change of treatment type can be applied prior to start of therapy to patients who carry a specific geno- or phenotype (i.e. actionable geno- or phenotypes). By doing so, increased efficacy of therapy or reduced risk of adverse events of treatment can be accomplished. In Denmark, broad implementation of PGx is currently still low. Objectives The aim of this study is to classify the PGx profiles of Danish individuals with and without severe mental disorders (SMD), to be used in follow-up studies investigating PGx and drug outcomes. Methods This study made use of imputed genotyping data of the Danish iPSYCH sample, which includes 77,639 young individuals born between 1981-2005, with or without a diagnosis of one or more of five selected SMD (i.e. depression, attention-deficit/hyperactivity disorder, autism, bipolar disorder and schizophrenia). We investigated a panel of 48 genetic variants with known PGx applications (part of the U-PGx consortium, a Horizon2020 funded project on clinical relevant PGx in the EU). Results Imputed data contains over 11 million SNPs of 77,639 individuals. Conclusions We expect results in the end of 2020. Disclosure We thank the iPSYCH consortium, in specific the iPSYCH PI’s (Merete Nordentoft, Anders Børglum, Preben B. Mortensen, Ole Mors, Thomas Werge and David M. Hougaard). The iPSYCH project is funded by the Lundbeck Foundation Denmark and the universities and un https://www.cambridge.org/core/product/identifier/S0924933821003965/type/journal_articlegenotypephenotypePharmacogenetics |
| spellingShingle | C. Lunenburg J. Thirstrup C. Gasse Pharmacogenetic profiles of young danish individuals with and without severe mental disorders European Psychiatry genotype phenotype Pharmacogenetics |
| title | Pharmacogenetic profiles of young danish individuals with and without severe mental disorders |
| title_full | Pharmacogenetic profiles of young danish individuals with and without severe mental disorders |
| title_fullStr | Pharmacogenetic profiles of young danish individuals with and without severe mental disorders |
| title_full_unstemmed | Pharmacogenetic profiles of young danish individuals with and without severe mental disorders |
| title_short | Pharmacogenetic profiles of young danish individuals with and without severe mental disorders |
| title_sort | pharmacogenetic profiles of young danish individuals with and without severe mental disorders |
| topic | genotype phenotype Pharmacogenetics |
| url | https://www.cambridge.org/core/product/identifier/S0924933821003965/type/journal_article |
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