Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer
Denise A Yardley1,2 1Sarah Cannon Research Institute, Nashville, TN, USA; 2Tennessee Oncology, Nashville, TN, USA Abstract: There is a high risk for bone loss and skeletal-related events, including bone metastases, in postmenopausal women with hormone receptor-positive breast cancer. Both the disea...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-05-01
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| Series: | Breast Cancer: Targets and Therapy |
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| Online Access: | https://www.dovepress.com/pharmacologic-management-of-bone-related-complications-and-bone-metast-peer-reviewed-article-BCTT |
| _version_ | 1818844393114697728 |
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| author | Yardley DA |
| author_facet | Yardley DA |
| author_sort | Yardley DA |
| collection | DOAJ |
| description | Denise A Yardley1,2 1Sarah Cannon Research Institute, Nashville, TN, USA; 2Tennessee Oncology, Nashville, TN, USA Abstract: There is a high risk for bone loss and skeletal-related events, including bone metastases, in postmenopausal women with hormone receptor-positive breast cancer. Both the disease itself and its therapeutic treatments can negatively impact bone, resulting in decreases in bone mineral density and increases in bone loss. These negative effects on the bone can significantly impact morbidity and mortality. Effective management and minimization of bone-related complications in postmenopausal women with hormone receptor-positive breast cancer remain essential. This review discusses the current understanding of molecular and biological mechanisms involved in bone turnover and metastases, increased risk for bone-related complications from breast cancer and breast cancer therapy, and current and emerging treatment strategies for managing bone metastases and bone turnover in postmenopausal women with hormone receptor-positive breast cancer. Keywords: breast cancer, bone metastases, hormone receptor-positive, bone-related complications, interventions, management and management strategies, estrogen receptor-positive |
| first_indexed | 2024-12-19T05:13:03Z |
| format | Article |
| id | doaj.art-269af8026fbc43f1ab786efcbd6a69cf |
| institution | Directory Open Access Journal |
| issn | 1179-1314 |
| language | English |
| last_indexed | 2024-12-19T05:13:03Z |
| publishDate | 2016-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj.art-269af8026fbc43f1ab786efcbd6a69cf2022-12-21T20:34:45ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142016-05-012016Issue 1738226733Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancerYardley DADenise A Yardley1,2 1Sarah Cannon Research Institute, Nashville, TN, USA; 2Tennessee Oncology, Nashville, TN, USA Abstract: There is a high risk for bone loss and skeletal-related events, including bone metastases, in postmenopausal women with hormone receptor-positive breast cancer. Both the disease itself and its therapeutic treatments can negatively impact bone, resulting in decreases in bone mineral density and increases in bone loss. These negative effects on the bone can significantly impact morbidity and mortality. Effective management and minimization of bone-related complications in postmenopausal women with hormone receptor-positive breast cancer remain essential. This review discusses the current understanding of molecular and biological mechanisms involved in bone turnover and metastases, increased risk for bone-related complications from breast cancer and breast cancer therapy, and current and emerging treatment strategies for managing bone metastases and bone turnover in postmenopausal women with hormone receptor-positive breast cancer. Keywords: breast cancer, bone metastases, hormone receptor-positive, bone-related complications, interventions, management and management strategies, estrogen receptor-positivehttps://www.dovepress.com/pharmacologic-management-of-bone-related-complications-and-bone-metast-peer-reviewed-article-BCTTbreast cancerbone metastaseshormone receptor positivebone-related complications |
| spellingShingle | Yardley DA Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer Breast Cancer: Targets and Therapy breast cancer bone metastases hormone receptor positive bone-related complications |
| title | Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer |
| title_full | Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer |
| title_fullStr | Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer |
| title_full_unstemmed | Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer |
| title_short | Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer |
| title_sort | pharmacologic management of bone related complications and bone metastases in postmenopausal women with hormone receptor positive breast cancer |
| topic | breast cancer bone metastases hormone receptor positive bone-related complications |
| url | https://www.dovepress.com/pharmacologic-management-of-bone-related-complications-and-bone-metast-peer-reviewed-article-BCTT |
| work_keys_str_mv | AT yardleyda pharmacologicmanagementofbonerelatedcomplicationsandbonemetastasesinpostmenopausalwomenwithhormonereceptorpositivebreastcancer |