Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable <italic toggle="yes">Haemophilus influenzae</italic>

Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable <italic toggle="yes">Haemophilus influenzae</italic>

ABSTRACT Biofilms formed in the middle ear by nontypeable Haemophilus influenzae (NTHI) are central to the chronicity, recurrence, and refractive nature of otitis media (OM). However, mechanisms that underlie the emergence of specific NTHI biofilm structures are unclear. We combined computational an...

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Bibliographic Details
Main Authors: Jayajit Das, Elaine Mokrzan, Vinal Lakhani, Lucia Rosas, Joseph A. Jurcisek, William C. Ray, Lauren O. Bakaletz
Format: Article
Language:English
Published: American Society for Microbiology 2017-12-01
Series:mBio
Subjects:
agent-based modeling
biofilms
nontypeable Haemophilus influenzae
otitis media
pair correlation
Online Access:https://journals.asm.org/doi/10.1128/mBio.01466-17

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