Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)

Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)

IntroductionSyphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum (Tp), is resurging globally. Tp’s repertoire of outer membrane proteins (OMPs) includes BamA (β-barrel assembly machinery subunit A/TP0326), a bipartite protein consisting of a 16-stranded β-barrel wit...

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Bibliographic Details
Main Authors: Mary R. Ferguson, Kristina N. Delgado, Shannon McBride, Isabel C. Orbe, Carson J. La Vake, Melissa J. Caimano, Qiana Mendez, Trevor F. Moraes, Anthony B. Schryvers, M. Anthony Moody, Justin D. Radolf, Michael P. Weiner, Kelly L. Hawley
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
syphilis
Treponema pallidum
outer membrane protein
BamA ECL4
opsonic antibody
monoclonal antibody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1222267/full

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