Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid Arthritis
<i>Background and Objectives</i>: Hematological indices have been known to be available markers used for evaluating disease activity in rheumatoid arthritis (RA). This study serves to verify the association between four different hematological indices and disease activity measures in pat...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/1/117 |
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| author | Jung-Yoon Choe Chan Uk Lee Seong-Kyu Kim |
| author_facet | Jung-Yoon Choe Chan Uk Lee Seong-Kyu Kim |
| author_sort | Jung-Yoon Choe |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Hematological indices have been known to be available markers used for evaluating disease activity in rheumatoid arthritis (RA). This study serves to verify the association between four different hematological indices and disease activity measures in patients with RA. <i>Materials and Methods</i>: The study included 257 female RA patients and 71 age-matched female controls. Four hematological indices, namely systemic immune-inflammation index (SII), neutrophil-to-hemoglobin and lymphocyte (NHL) score, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), were evaluated. Composite measures of RA included Disease Activity Score 28 joints (DAS28), the simplified disease activity index (SDAI), and the clinical disease activity index (CDAI). <i>Results</i>: Patients with RA showed statistically higher SII, NHL score, NLR, and PLR compared with controls. SII and NHL score were significantly associated with DAS28 erythrocyte sedimentation rate (DAS28-ESR), DAS28 C-reactive protein (DAS28-CRP), CDAI, and SDAI, whereas NLR was related to DAS28-CRP, CDAI, and SDAI. SII, NHL score, and NLR tended to increase as disease activity based on DAS28-ESR, DAS28-CRP, and CDAI worsened. In the analysis using receiver operating characteristic curve of hematological indices for diagnostic accuracy, the area under the curve was 0.703 (95% confidence interval, CI 0.637–0.769, <i>p</i> < 0.001) for SII and 0.705 (95% CI 0.639–0.770, <i>p</i> < 0.001) for NHL score, which showed acceptable potential for the diagnosis of RA. Four hematological indices showed weak potential for the detection of remission. <i>Conclusions</i>: The present study results showed that SII and NHL scores might be useful markers that adequately reflect disease activity and lead to more accurate diagnosis in RA. |
| first_indexed | 2024-03-09T11:44:15Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T11:44:15Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-26a063ede0da4582bf9fa67cc0219bf32023-11-30T23:24:35ZengMDPI AGMedicina1010-660X1648-91442023-01-0159111710.3390/medicina59010117Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid ArthritisJung-Yoon Choe0Chan Uk Lee1Seong-Kyu Kim2Division of Rheumatology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu 42472, Republic of KoreaDepartment of Internal Medicine, Kwak’s Hospital, Daegu 41919, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu 42472, Republic of Korea<i>Background and Objectives</i>: Hematological indices have been known to be available markers used for evaluating disease activity in rheumatoid arthritis (RA). This study serves to verify the association between four different hematological indices and disease activity measures in patients with RA. <i>Materials and Methods</i>: The study included 257 female RA patients and 71 age-matched female controls. Four hematological indices, namely systemic immune-inflammation index (SII), neutrophil-to-hemoglobin and lymphocyte (NHL) score, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), were evaluated. Composite measures of RA included Disease Activity Score 28 joints (DAS28), the simplified disease activity index (SDAI), and the clinical disease activity index (CDAI). <i>Results</i>: Patients with RA showed statistically higher SII, NHL score, NLR, and PLR compared with controls. SII and NHL score were significantly associated with DAS28 erythrocyte sedimentation rate (DAS28-ESR), DAS28 C-reactive protein (DAS28-CRP), CDAI, and SDAI, whereas NLR was related to DAS28-CRP, CDAI, and SDAI. SII, NHL score, and NLR tended to increase as disease activity based on DAS28-ESR, DAS28-CRP, and CDAI worsened. In the analysis using receiver operating characteristic curve of hematological indices for diagnostic accuracy, the area under the curve was 0.703 (95% confidence interval, CI 0.637–0.769, <i>p</i> < 0.001) for SII and 0.705 (95% CI 0.639–0.770, <i>p</i> < 0.001) for NHL score, which showed acceptable potential for the diagnosis of RA. Four hematological indices showed weak potential for the detection of remission. <i>Conclusions</i>: The present study results showed that SII and NHL scores might be useful markers that adequately reflect disease activity and lead to more accurate diagnosis in RA.https://www.mdpi.com/1648-9144/59/1/117rheumatoid arthritishematological indexcomposite measuredisease activity |
| spellingShingle | Jung-Yoon Choe Chan Uk Lee Seong-Kyu Kim Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid Arthritis Medicina rheumatoid arthritis hematological index composite measure disease activity |
| title | Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid Arthritis |
| title_full | Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid Arthritis |
| title_fullStr | Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid Arthritis |
| title_full_unstemmed | Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid Arthritis |
| title_short | Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid Arthritis |
| title_sort | association between novel hematological indices and measures of disease activity in patients with rheumatoid arthritis |
| topic | rheumatoid arthritis hematological index composite measure disease activity |
| url | https://www.mdpi.com/1648-9144/59/1/117 |
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