Increasing maternal age associates with lower placental CPT1B mRNA expression and acylcarnitines, particularly in overweight women

Increasing maternal age associates with lower placental CPT1B mRNA expression and acylcarnitines, particularly in overweight women

Older pregnant women have increased risks of complications including gestational diabetes and stillbirth. Carnitine palmitoyl transferase (CPT) expression declines with age in several tissues and is linked with poorer metabolic health. Mitochondrial CPTs catalyze acylcarnitine synthesis, which facil...

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Bibliographic Details
Main Authors: Hannah E. J. Yong, Oliver C. Watkins, Tania K. L. Mah, Victoria K. B. Cracknell-Hazra, Reshma Appukuttan Pillai, Preben Selvam, Mohammad O. Islam, Neha Sharma, Amaury Cazenave-Gassiot, Anne K. Bendt, Markus R. Wenk, Keith M. Godfrey, Rohan M. Lewis, Shiao-Yng Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Physiology
Subjects:
placenta
maternal age
lipid metabolism
carnitine palmitoyltransferases
obesity
overweight
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1166827/full

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