Orexins and bipolar disorder: A review
Introduction Bipolar disorder (BD) is a chronic deteriorating illness which has a strong impact on functionality. In the past few years, orexins have gained importance as possible biomarkers of circadian rhythms, affected in BD. Up to this date, we have not found any bibliographical review evaluati...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822010148/type/journal_article |
| _version_ | 1797616117085110272 |
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| author | C. Moya Lacasa L. Gonzalez-Blanco C. Martinez-Cao C.M. Alvarez-Vazquez E. Martin-Gil A. García Fernández P.A. Saiz J. Bobes M.P. Garcia-Portilla |
| author_facet | C. Moya Lacasa L. Gonzalez-Blanco C. Martinez-Cao C.M. Alvarez-Vazquez E. Martin-Gil A. García Fernández P.A. Saiz J. Bobes M.P. Garcia-Portilla |
| author_sort | C. Moya Lacasa |
| collection | DOAJ |
| description |
Introduction
Bipolar disorder (BD) is a chronic deteriorating illness which has a strong impact on functionality. In the past few years, orexins have gained importance as possible biomarkers of circadian rhythms, affected in BD. Up to this date, we have not found any bibliographical review evaluating the association of orexins and BD.
Objectives
To review published literature in relation to the associaton of orexins and BD.
Methods
A bibliographical search was conducted in PubMed. Inclusion criteria were a) the study evaluated orexins in plasma or cerebrospinal fluid, and b) patients with BD were included within the subjects of study.
Reference lists of the articles that met inclusion criteria were also examined.
Results
Ten articles were retrieved from the initial search. Only three met inclusion criteria and another one was selected from the reference list examination. One study observed significantly higher levels of orexin A in plasma of BD patients versus depression and controls. Other found higher concentration of orexin A of unipolar and bipolar depression versus controls, but this result was not statistically significant. Another one did not find differences in orexin A concentration between mania, depression and controls. The remaining study detected significantly lower concentration of orexin A in BD versus depression, schizophrenia and controls.
Conclusions
Despite being heterogenous, the results point out there are differences in orexin levels in BD when compared to other diagnostic groups or controls. This sets a starting point to focus research on this subject and continue analyzing the role of orexins as biomarkers in BD.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:36:43Z |
| format | Article |
| id | doaj.art-26a12ba91f11401e947380bb4ab2e000 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:36:43Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-26a12ba91f11401e947380bb4ab2e0002023-11-17T05:09:24ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S400S40010.1192/j.eurpsy.2022.1014Orexins and bipolar disorder: A reviewC. Moya Lacasa0L. Gonzalez-Blanco1C. Martinez-Cao2C.M. Alvarez-Vazquez3E. Martin-Gil4A. García Fernández5P.A. Saiz6J. Bobes7M.P. Garcia-Portilla8University of Oviedo, Department Of Psychiatry, Oviedo, SpainUniversity of Oviedo, Department Of Psychiatry, oviedo, SpainUniversity of Oviedo, Department Of Psychiatry, oviedo, SpainUniversity of Oviedo, Department Of Psychiatry, Oviedo, SpainUniversity of Oviedo, Department Of Psychiatry, oviedo, SpainUniversity of Oviedo, Department Of Psychiatry, Oviedo, SpainUniversity of Oviedo, Department Of Psychiatry, Oviedo, SpainUniversity of Oviedo, Department Of Psychiatry, Oviedo, SpainUniversity of Oviedo, Department Of Psychiatry, oviedo, Spain Introduction Bipolar disorder (BD) is a chronic deteriorating illness which has a strong impact on functionality. In the past few years, orexins have gained importance as possible biomarkers of circadian rhythms, affected in BD. Up to this date, we have not found any bibliographical review evaluating the association of orexins and BD. Objectives To review published literature in relation to the associaton of orexins and BD. Methods A bibliographical search was conducted in PubMed. Inclusion criteria were a) the study evaluated orexins in plasma or cerebrospinal fluid, and b) patients with BD were included within the subjects of study. Reference lists of the articles that met inclusion criteria were also examined. Results Ten articles were retrieved from the initial search. Only three met inclusion criteria and another one was selected from the reference list examination. One study observed significantly higher levels of orexin A in plasma of BD patients versus depression and controls. Other found higher concentration of orexin A of unipolar and bipolar depression versus controls, but this result was not statistically significant. Another one did not find differences in orexin A concentration between mania, depression and controls. The remaining study detected significantly lower concentration of orexin A in BD versus depression, schizophrenia and controls. Conclusions Despite being heterogenous, the results point out there are differences in orexin levels in BD when compared to other diagnostic groups or controls. This sets a starting point to focus research on this subject and continue analyzing the role of orexins as biomarkers in BD. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822010148/type/journal_articlehypocretincircadian rhythmsbipolar disorderorexins |
| spellingShingle | C. Moya Lacasa L. Gonzalez-Blanco C. Martinez-Cao C.M. Alvarez-Vazquez E. Martin-Gil A. García Fernández P.A. Saiz J. Bobes M.P. Garcia-Portilla Orexins and bipolar disorder: A review European Psychiatry hypocretin circadian rhythms bipolar disorder orexins |
| title | Orexins and bipolar disorder: A review |
| title_full | Orexins and bipolar disorder: A review |
| title_fullStr | Orexins and bipolar disorder: A review |
| title_full_unstemmed | Orexins and bipolar disorder: A review |
| title_short | Orexins and bipolar disorder: A review |
| title_sort | orexins and bipolar disorder a review |
| topic | hypocretin circadian rhythms bipolar disorder orexins |
| url | https://www.cambridge.org/core/product/identifier/S0924933822010148/type/journal_article |
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