β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis
Uterine disease: Regulatory pathways identified A regulatory link between two proteins involved in the progression of a debilitating uterine condition highlights a potential therapeutic target. Adenomyosis involves the invasion of cells from the inner lining of the uterus (the endometrium) into the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-10-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-00514-6 |
| _version_ | 1818724746545594368 |
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| author | Jung-Yoon Yoo Bon Jeong Ku Tae Hoon Kim Jong Il Ahn Ji Yeon Ahn Woo Sub Yang Jeong Mook Lim Maketo M. Taketo Jung-Ho Shin Jae-Wook Jeong |
| author_facet | Jung-Yoon Yoo Bon Jeong Ku Tae Hoon Kim Jong Il Ahn Ji Yeon Ahn Woo Sub Yang Jeong Mook Lim Maketo M. Taketo Jung-Ho Shin Jae-Wook Jeong |
| author_sort | Jung-Yoon Yoo |
| collection | DOAJ |
| description | Uterine disease: Regulatory pathways identified A regulatory link between two proteins involved in the progression of a debilitating uterine condition highlights a potential therapeutic target. Adenomyosis involves the invasion of cells from the inner lining of the uterus (the endometrium) into the uterine muscle wall (the myometrium), resulting in heavy, prolonged periods and chronic pain. The aberrent activation of a protein called β-catenin triggers adenomyosis, but the precise mechanisms are unclear. A team led by Jung-Ho Shin at the Korea University Medical Center, Seoul, South Korea, and Jae-Wook Jeong, Michigan State University, Grand Rapids, USA, used sequencing techniques in mice and human tissue samples to identify the pathways governed by β-catenin in adenomyosis. They found that the Tgf-β2 gene is directly regulated by β-catenin in the uterus. TGF-β2 levels were elevated in human adenomyosis lesions, suggesting the protein could be a therapeutic target. |
| first_indexed | 2024-12-17T21:31:19Z |
| format | Article |
| id | doaj.art-26a3b4cda87345c38cf82f7c97720e23 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-17T21:31:19Z |
| publishDate | 2020-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-26a3b4cda87345c38cf82f7c97720e232022-12-21T21:31:52ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-10-0152101754176510.1038/s12276-020-00514-6β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosisJung-Yoon Yoo0Bon Jeong Ku1Tae Hoon Kim2Jong Il Ahn3Ji Yeon Ahn4Woo Sub Yang5Jeong Mook Lim6Maketo M. Taketo7Jung-Ho Shin8Jae-Wook Jeong9Department of Biochemistry and Molecular Biology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of MedicineDepartment of Internal Medicine, Chungnam National University College of MedicineDepartment of Obstetrics, Gynecology, & Reproductive Biology, Michigan State UniversityDepartment of Agricultural Biotechnology, Seoul National UniversityResearch Institutes of Agriculture and Life Sciences, Seoul National UniversityDepartment of Agricultural Biotechnology, Seoul National UniversityDepartment of Agricultural Biotechnology, Seoul National UniversityDivision of Experimental Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, SakyoDivision of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Guro Hospital, Korea University Medical CenterDepartment of Obstetrics, Gynecology, & Reproductive Biology, Michigan State UniversityUterine disease: Regulatory pathways identified A regulatory link between two proteins involved in the progression of a debilitating uterine condition highlights a potential therapeutic target. Adenomyosis involves the invasion of cells from the inner lining of the uterus (the endometrium) into the uterine muscle wall (the myometrium), resulting in heavy, prolonged periods and chronic pain. The aberrent activation of a protein called β-catenin triggers adenomyosis, but the precise mechanisms are unclear. A team led by Jung-Ho Shin at the Korea University Medical Center, Seoul, South Korea, and Jae-Wook Jeong, Michigan State University, Grand Rapids, USA, used sequencing techniques in mice and human tissue samples to identify the pathways governed by β-catenin in adenomyosis. They found that the Tgf-β2 gene is directly regulated by β-catenin in the uterus. TGF-β2 levels were elevated in human adenomyosis lesions, suggesting the protein could be a therapeutic target.https://doi.org/10.1038/s12276-020-00514-6 |
| spellingShingle | Jung-Yoon Yoo Bon Jeong Ku Tae Hoon Kim Jong Il Ahn Ji Yeon Ahn Woo Sub Yang Jeong Mook Lim Maketo M. Taketo Jung-Ho Shin Jae-Wook Jeong β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis Experimental and Molecular Medicine |
| title | β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis |
| title_full | β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis |
| title_fullStr | β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis |
| title_full_unstemmed | β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis |
| title_short | β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis |
| title_sort | β catenin activates tgf β induced epithelial mesenchymal transition in adenomyosis |
| url | https://doi.org/10.1038/s12276-020-00514-6 |
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