Effect of chlorhexidine Mouthrinse on prevention of microbial contamination during EBUS-TBNA: a randomized controlled trial
Abstract Background Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure, fatal infectious complications have been reported. However, adequate preventive strategies have not been determined. We aimed to investigate the effect of chlo...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-10442-5 |
| _version_ | 1828087002742915072 |
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| author | Na Young Kim Jae Hyeon Park Jimyung Park Nakwon Kwak Sun Mi Choi Young Sik Park Chang-Hoon Lee Jaeyoung Cho |
| author_facet | Na Young Kim Jae Hyeon Park Jimyung Park Nakwon Kwak Sun Mi Choi Young Sik Park Chang-Hoon Lee Jaeyoung Cho |
| author_sort | Na Young Kim |
| collection | DOAJ |
| description | Abstract Background Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure, fatal infectious complications have been reported. However, adequate preventive strategies have not been determined. We aimed to investigate the effect of chlorhexidine mouthrinse on the prevention of microbial contamination during EBUS-TBNA. Methods In this single-center, assessor-blinded, parallel-group randomized controlled trial, we randomly assigned adult participants undergoing EBUS-TBNA using a convex probe to gargle for 1 minute with 100 mL of 0.12% chlorhexidine gluconate before EBUS-TBNA or to receive usual care (no chlorhexidine mouthrinse). Aspiration needle wash samples were collected immediately after completion of EBUS-TBNA by instilling sterile saline into the used needle. The primary outcome was colony forming unit (CFU) counts per mL of needle wash samples in aerobic cultures. Secondary outcomes were CFU counts per mL of needle wash samples in anaerobic cultures, fever within 24 hours after EBUS-TBNA, and infectious complications within 4 weeks after EBUS-TBNA. Results From January 2021 to June 2021, 106 patients received either chlorhexidine mouthrinse (n = 51) or usual care (n = 55). The median CFU counts of needle wash samples in aerobic cultures were not significantly different in the two groups (10 CFU/mL vs 20 CFU/mL; P = 0.70). There were no significant differences between the groups regarding secondary outcomes, including median CFU counts in anaerobic cultures (P = 0.41) and fever within 24 hours after EBUS-TBNA (11.8% vs 5.6%, P = 0.31). There were no infectious complications within 4 weeks in both groups. Conclusions Chlorhexidine mouthrinse did not reduce CFU counts in needle wash samples of EBUS-TBNA. Trial registration ClinicalTrials.gov, NCT04718922 . Registered on 22/01/2021. |
| first_indexed | 2024-04-11T05:06:06Z |
| format | Article |
| id | doaj.art-26a420e3b3c04c979924d5211a290607 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-11T05:06:06Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-26a420e3b3c04c979924d5211a2906072022-12-25T12:19:32ZengBMCBMC Cancer1471-24072022-12-0122111110.1186/s12885-022-10442-5Effect of chlorhexidine Mouthrinse on prevention of microbial contamination during EBUS-TBNA: a randomized controlled trialNa Young Kim0Jae Hyeon Park1Jimyung Park2Nakwon Kwak3Sun Mi Choi4Young Sik Park5Chang-Hoon Lee6Jaeyoung Cho7Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDepartment of Laboratory Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University HospitalAbstract Background Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure, fatal infectious complications have been reported. However, adequate preventive strategies have not been determined. We aimed to investigate the effect of chlorhexidine mouthrinse on the prevention of microbial contamination during EBUS-TBNA. Methods In this single-center, assessor-blinded, parallel-group randomized controlled trial, we randomly assigned adult participants undergoing EBUS-TBNA using a convex probe to gargle for 1 minute with 100 mL of 0.12% chlorhexidine gluconate before EBUS-TBNA or to receive usual care (no chlorhexidine mouthrinse). Aspiration needle wash samples were collected immediately after completion of EBUS-TBNA by instilling sterile saline into the used needle. The primary outcome was colony forming unit (CFU) counts per mL of needle wash samples in aerobic cultures. Secondary outcomes were CFU counts per mL of needle wash samples in anaerobic cultures, fever within 24 hours after EBUS-TBNA, and infectious complications within 4 weeks after EBUS-TBNA. Results From January 2021 to June 2021, 106 patients received either chlorhexidine mouthrinse (n = 51) or usual care (n = 55). The median CFU counts of needle wash samples in aerobic cultures were not significantly different in the two groups (10 CFU/mL vs 20 CFU/mL; P = 0.70). There were no significant differences between the groups regarding secondary outcomes, including median CFU counts in anaerobic cultures (P = 0.41) and fever within 24 hours after EBUS-TBNA (11.8% vs 5.6%, P = 0.31). There were no infectious complications within 4 weeks in both groups. Conclusions Chlorhexidine mouthrinse did not reduce CFU counts in needle wash samples of EBUS-TBNA. Trial registration ClinicalTrials.gov, NCT04718922 . Registered on 22/01/2021.https://doi.org/10.1186/s12885-022-10442-5Chlorhexidine gluconateEBUS-TBNAInfectious complicationMouthrinse |
| spellingShingle | Na Young Kim Jae Hyeon Park Jimyung Park Nakwon Kwak Sun Mi Choi Young Sik Park Chang-Hoon Lee Jaeyoung Cho Effect of chlorhexidine Mouthrinse on prevention of microbial contamination during EBUS-TBNA: a randomized controlled trial BMC Cancer Chlorhexidine gluconate EBUS-TBNA Infectious complication Mouthrinse |
| title | Effect of chlorhexidine Mouthrinse on prevention of microbial contamination during EBUS-TBNA: a randomized controlled trial |
| title_full | Effect of chlorhexidine Mouthrinse on prevention of microbial contamination during EBUS-TBNA: a randomized controlled trial |
| title_fullStr | Effect of chlorhexidine Mouthrinse on prevention of microbial contamination during EBUS-TBNA: a randomized controlled trial |
| title_full_unstemmed | Effect of chlorhexidine Mouthrinse on prevention of microbial contamination during EBUS-TBNA: a randomized controlled trial |
| title_short | Effect of chlorhexidine Mouthrinse on prevention of microbial contamination during EBUS-TBNA: a randomized controlled trial |
| title_sort | effect of chlorhexidine mouthrinse on prevention of microbial contamination during ebus tbna a randomized controlled trial |
| topic | Chlorhexidine gluconate EBUS-TBNA Infectious complication Mouthrinse |
| url | https://doi.org/10.1186/s12885-022-10442-5 |
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