Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>
ABSTRACT The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yea...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2019-08-01
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| Series: | mSphere |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mSphere.00458-19 |
| _version_ | 1818856747649990656 |
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| author | Ryan Kean Gordon Ramage |
| author_facet | Ryan Kean Gordon Ramage |
| author_sort | Ryan Kean |
| collection | DOAJ |
| description | ABSTRACT The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yeast has spread globally, its clinical importance, and how it tolerates and resists antifungal agents has expanded. This review highlights the clinical importance of antifungal resistance in C. auris and explores our current understanding of the mechanisms associated with azole, polyene, and echinocandin resistance. We also discuss the impact of phenotypic tolerance, with particular emphasis on biofilm-mediated resistance, and present new pipelines of antifungal drugs that promise new hope in the management of C. auris infection. |
| first_indexed | 2024-12-19T08:29:25Z |
| format | Article |
| id | doaj.art-26a53634015443a9b3763c7ec760007c |
| institution | Directory Open Access Journal |
| issn | 2379-5042 |
| language | English |
| last_indexed | 2024-12-19T08:29:25Z |
| publishDate | 2019-08-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mSphere |
| spelling | doaj.art-26a53634015443a9b3763c7ec760007c2022-12-21T20:29:13ZengAmerican Society for MicrobiologymSphere2379-50422019-08-014410.1128/mSphere.00458-19Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>Ryan Kean0Gordon Ramage1Department of Biological and Biomedical Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, United KingdomOral Sciences Research Group, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United KingdomABSTRACT The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yeast has spread globally, its clinical importance, and how it tolerates and resists antifungal agents has expanded. This review highlights the clinical importance of antifungal resistance in C. auris and explores our current understanding of the mechanisms associated with azole, polyene, and echinocandin resistance. We also discuss the impact of phenotypic tolerance, with particular emphasis on biofilm-mediated resistance, and present new pipelines of antifungal drugs that promise new hope in the management of C. auris infection.https://journals.asm.org/doi/10.1128/mSphere.00458-19Candidaantifungal resistancebiofilmstolerance |
| spellingShingle | Ryan Kean Gordon Ramage Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content> mSphere Candida antifungal resistance biofilms tolerance |
| title | Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content> |
| title_full | Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content> |
| title_fullStr | Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content> |
| title_full_unstemmed | Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content> |
| title_short | Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content> |
| title_sort | combined antifungal resistance and biofilm tolerance the global threat of named content content type genus species candida auris named content |
| topic | Candida antifungal resistance biofilms tolerance |
| url | https://journals.asm.org/doi/10.1128/mSphere.00458-19 |
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