Unveiling the antitumor potential of novel N-(substituted-phenyl)-8-methoxycoumarin-3-carboxamides as dual inhibitors of VEGFR2 kinase and cytochrome P450 for targeted treatment of hepatocellular carcinoma

Unveiling the antitumor potential of novel N-(substituted-phenyl)-8-methoxycoumarin-3-carboxamides as dual inhibitors of VEGFR2 kinase and cytochrome P450 for targeted treatment of hepatocellular carcinoma

Being the sixth most diagnosed cancer and the fourth leading cause of cancer-related deaths worldwide, liver cancer is considered as a serious disease with a high prevalence and poor prognosis. Current anticancer drugs for liver cancer have drawbacks, such as limited efficacy in later stages of the...

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Bibliographic Details
Main Authors: Eman M. Radwan, Eman Abo-Elabass, Atef E. Abd El-Baky, Hussah Abdullah Alshwyeh, Riyad A. Almaimani, Ghassan Almaimani, Ibrahim Abdel Aziz Ibrahim, Abdulaziz Albogami, Mariusz Jaremko, Samar Z. Alshawwa, Essa M. Saied
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Chemistry
Subjects:
coumarin
hepatocellular carcinoma
cytotoxicity
cell arrest
apoptosis
cytochrome P450
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1231030/full

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