Theta oscillations in prolactinomas: Neurocognitive deficits in executive controls
Impairment of cognitive functions has been reported in prolactinomas. However, the electrophysiological mechanisms of response activation and response inhibition in prolactinomas remain unclear. We recorded participants’ scalp electroencephalography (EEG) in a visual Go/Nogo task. Compared to the he...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158220302928 |
| _version_ | 1818390221650132992 |
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| author | Chenglong Cao Wen Wen Binbin Liu Pan Ma Sheng Li Guozheng Xu Jian Song |
| author_facet | Chenglong Cao Wen Wen Binbin Liu Pan Ma Sheng Li Guozheng Xu Jian Song |
| author_sort | Chenglong Cao |
| collection | DOAJ |
| description | Impairment of cognitive functions has been reported in prolactinomas. However, the electrophysiological mechanisms of response activation and response inhibition in prolactinomas remain unclear. We recorded participants’ scalp electroencephalography (EEG) in a visual Go/Nogo task. Compared to the healthy controls (HCs), the patients demonstrated worse performance and their prolactin (PRL) levels negatively correlated with behavioral results. Meanwhile, patients’ P300 amplitudes in the Go and Nogo conditions were smaller than the HCs. The amplitudes of N200nogo in patients were smaller than the HCs as well. Lower frontal theta power was found in the patients than the HCs in both Go and Nogo conditions, which indicated a deficit in response activation and inhibition. Moreover, the PRL levels mediated the relationship between frontal theta power and behavior performance, implying that lower frontal theta power caused the dysfunction of response control by abnormally high PRL levels. Patients also showed lower occipital alpha power than the HCs, which suggested that the impaired response inhibition may arise from deficient attention control. Taken together, the present study revealed the neurocognitive discrepancies between prolactinomas and the HCs. The frontal theta oscillation was highlighted as the electrophysiological markers of the impaired response control in prolactinomas. |
| first_indexed | 2024-12-14T04:54:11Z |
| format | Article |
| id | doaj.art-26a70650f65e4923817012a73586abcc |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-14T04:54:11Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-26a70650f65e4923817012a73586abcc2022-12-21T23:16:27ZengElsevierNeuroImage: Clinical2213-15822020-01-0128102455Theta oscillations in prolactinomas: Neurocognitive deficits in executive controlsChenglong Cao0Wen Wen1Binbin Liu2Pan Ma3Sheng Li4Guozheng Xu5Jian Song6The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; Department of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan 430070, ChinaSchool of Psychological and Cognitive Sciences, Peking University, Beijing 100871, ChinaWuhan University of Science and Technology, Wuhan 430000, ChinaWuhan Children's Hospital, Tongji Medical College of Huazhong University of Science & Technology, ChinaSchool of Psychological and Cognitive Sciences, Peking University, Beijing 100871, ChinaThe First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; Department of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan 430070, China; Corresponding authors at: Department of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan 430070, China.Department of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan 430070, China; Corresponding authors at: Department of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan 430070, China.Impairment of cognitive functions has been reported in prolactinomas. However, the electrophysiological mechanisms of response activation and response inhibition in prolactinomas remain unclear. We recorded participants’ scalp electroencephalography (EEG) in a visual Go/Nogo task. Compared to the healthy controls (HCs), the patients demonstrated worse performance and their prolactin (PRL) levels negatively correlated with behavioral results. Meanwhile, patients’ P300 amplitudes in the Go and Nogo conditions were smaller than the HCs. The amplitudes of N200nogo in patients were smaller than the HCs as well. Lower frontal theta power was found in the patients than the HCs in both Go and Nogo conditions, which indicated a deficit in response activation and inhibition. Moreover, the PRL levels mediated the relationship between frontal theta power and behavior performance, implying that lower frontal theta power caused the dysfunction of response control by abnormally high PRL levels. Patients also showed lower occipital alpha power than the HCs, which suggested that the impaired response inhibition may arise from deficient attention control. Taken together, the present study revealed the neurocognitive discrepancies between prolactinomas and the HCs. The frontal theta oscillation was highlighted as the electrophysiological markers of the impaired response control in prolactinomas.http://www.sciencedirect.com/science/article/pii/S2213158220302928ProlactinomasTheta oscillationP300N200Response activation and inhibition |
| spellingShingle | Chenglong Cao Wen Wen Binbin Liu Pan Ma Sheng Li Guozheng Xu Jian Song Theta oscillations in prolactinomas: Neurocognitive deficits in executive controls NeuroImage: Clinical Prolactinomas Theta oscillation P300 N200 Response activation and inhibition |
| title | Theta oscillations in prolactinomas: Neurocognitive deficits in executive controls |
| title_full | Theta oscillations in prolactinomas: Neurocognitive deficits in executive controls |
| title_fullStr | Theta oscillations in prolactinomas: Neurocognitive deficits in executive controls |
| title_full_unstemmed | Theta oscillations in prolactinomas: Neurocognitive deficits in executive controls |
| title_short | Theta oscillations in prolactinomas: Neurocognitive deficits in executive controls |
| title_sort | theta oscillations in prolactinomas neurocognitive deficits in executive controls |
| topic | Prolactinomas Theta oscillation P300 N200 Response activation and inhibition |
| url | http://www.sciencedirect.com/science/article/pii/S2213158220302928 |
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