The Host’s Reply to Candida Biofilm
Candida spp. are among the most common nosocomial fungal pathogens and are notorious for their propensity toward biofilm formation. When growing on a medical device or mucosal surface, these organisms reside as communities embedded in a protective matrix, resisting host defenses. The host responds t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-03-01
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| Series: | Pathogens |
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| Online Access: | http://www.mdpi.com/2076-0817/5/1/33 |
| _version_ | 1798041775887089664 |
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| author | Jeniel E. Nett |
| author_facet | Jeniel E. Nett |
| author_sort | Jeniel E. Nett |
| collection | DOAJ |
| description | Candida spp. are among the most common nosocomial fungal pathogens and are notorious for their propensity toward biofilm formation. When growing on a medical device or mucosal surface, these organisms reside as communities embedded in a protective matrix, resisting host defenses. The host responds to Candida biofilm by depositing a variety of proteins that become incorporated into the biofilm matrix. Compared to free-floating Candida, leukocytes are less effective against Candida within a biofilm. This review highlights recent advances describing the host’s response to Candida biofilms using ex vivo and in vivo models of mucosal and device-associated biofilm infections. |
| first_indexed | 2024-04-11T22:26:19Z |
| format | Article |
| id | doaj.art-26a8d751967e4829b6881a61e844bc0e |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-11T22:26:19Z |
| publishDate | 2016-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-26a8d751967e4829b6881a61e844bc0e2022-12-22T03:59:38ZengMDPI AGPathogens2076-08172016-03-01513310.3390/pathogens5010033pathogens5010033The Host’s Reply to Candida BiofilmJeniel E. Nett0University of Wisconsin-Madison, Departments of Medicine, Medical Microbiology and Immunology, 5203 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706, USACandida spp. are among the most common nosocomial fungal pathogens and are notorious for their propensity toward biofilm formation. When growing on a medical device or mucosal surface, these organisms reside as communities embedded in a protective matrix, resisting host defenses. The host responds to Candida biofilm by depositing a variety of proteins that become incorporated into the biofilm matrix. Compared to free-floating Candida, leukocytes are less effective against Candida within a biofilm. This review highlights recent advances describing the host’s response to Candida biofilms using ex vivo and in vivo models of mucosal and device-associated biofilm infections.http://www.mdpi.com/2076-0817/5/1/33Candidabiofilmhostneutrophilmodelmucosaldefensematrixmonocyte |
| spellingShingle | Jeniel E. Nett The Host’s Reply to Candida Biofilm Pathogens Candida biofilm host neutrophil model mucosal defense matrix monocyte |
| title | The Host’s Reply to Candida Biofilm |
| title_full | The Host’s Reply to Candida Biofilm |
| title_fullStr | The Host’s Reply to Candida Biofilm |
| title_full_unstemmed | The Host’s Reply to Candida Biofilm |
| title_short | The Host’s Reply to Candida Biofilm |
| title_sort | host s reply to candida biofilm |
| topic | Candida biofilm host neutrophil model mucosal defense matrix monocyte |
| url | http://www.mdpi.com/2076-0817/5/1/33 |
| work_keys_str_mv | AT jenielenett thehostsreplytocandidabiofilm AT jenielenett hostsreplytocandidabiofilm |