Evaluation of IL-8 level in cerebrospinal fluid in acute bacterial meningitis in adults
Background: Interleukin 8 increases in various types of meningitis, specifically acute bacterial meningitis inflammation, and it is important in the distinction between types of meningitis. The present paper aims at evaluation of the level of interleukin 8 in cerebrospinal fluid in acute adult bacte...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Tabriz University of Medical Sciences
2021-02-01
|
| Series: | مجله پزشکی دانشگاه علوم پزشکی تبریز |
| Subjects: | |
| Online Access: | https://mj.tbzmed.ac.ir/PDF/mj-42-6-634.pdf |
| _version_ | 1797962258118082560 |
|---|---|
| author | Zhinous Bayat-Makoo Puran Karimi Negar Mohtadi |
| author_facet | Zhinous Bayat-Makoo Puran Karimi Negar Mohtadi |
| author_sort | Zhinous Bayat-Makoo |
| collection | DOAJ |
| description | Background: Interleukin 8 increases in various types of meningitis, specifically acute bacterial meningitis inflammation, and it is important in the distinction between types of meningitis. The present paper aims at evaluation of the level of interleukin 8 in cerebrospinal fluid in acute adult bacterial meningitis. Methods: All adult patients’ with diagnosis of suspected meningitis with symptoms of fever, headache, neck stiffness, and consciousness disorder. Lumbar puncture was taken in between the third and fourth vertebra by a specialist physician for all patients suspected with meningitis. To determine the level of consciousness, the GCS of the patients was determined and the cerebrospinal fluid was cultured and sent to the laboratory for the analyses of cell count, diffraction, CSF fluid glucose, CSF fluid protein, LDH, or lactate dehydrogenase, and the level of interleukin 8. Results: The mean of IL-8 protein was 296.17±48.57Pg/ml in patients with aseptic meningitis and 1088.96±526.55Pg/ml in the group of patients with septic meningitis. There was a significant difference between the two groups in terms of the amount of interleukin 8 (p = 0.009). Cutoff was 297.6 Pg/ml for the detection of positive bacterial meningitis with a sensitivity of 92% and the specificity of 83.1% was 297.6 pg/ml. Conclusion: Interleukin 8 has a high sensitivity and specificity in the diagnosis of bacterial meningitis from aseptic meningitis, and along with the measurement of cerebrospinal fluid protein, it can be a good criterion for differentiation of bacterial from aseptic meningitis. |
| first_indexed | 2024-04-11T01:10:32Z |
| format | Article |
| id | doaj.art-26aa0fd8106f4cec9c2e1d393040c099 |
| institution | Directory Open Access Journal |
| issn | 2783-2031 2783-204X |
| language | fas |
| last_indexed | 2024-04-11T01:10:32Z |
| publishDate | 2021-02-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | مجله پزشکی دانشگاه علوم پزشکی تبریز |
| spelling | doaj.art-26aa0fd8106f4cec9c2e1d393040c0992023-01-04T06:29:24ZfasTabriz University of Medical Sciencesمجله پزشکی دانشگاه علوم پزشکی تبریز2783-20312783-204X2021-02-0142663464110.34172/mj.2021.00326031Evaluation of IL-8 level in cerebrospinal fluid in acute bacterial meningitis in adultsZhinous Bayat-Makoo0Puran Karimi1Negar Mohtadi2Department of Infectious and Tropical Disease, Infectious and Tropical Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Clinical Biochemistry, Tabriz University of Medical Sciences, Tabriz, IranStudent, Department of Infectious and Tropical Disease, Infectious and Tropical Research Center, Tabriz University of Medical Sciences, Tabriz, IranBackground: Interleukin 8 increases in various types of meningitis, specifically acute bacterial meningitis inflammation, and it is important in the distinction between types of meningitis. The present paper aims at evaluation of the level of interleukin 8 in cerebrospinal fluid in acute adult bacterial meningitis. Methods: All adult patients’ with diagnosis of suspected meningitis with symptoms of fever, headache, neck stiffness, and consciousness disorder. Lumbar puncture was taken in between the third and fourth vertebra by a specialist physician for all patients suspected with meningitis. To determine the level of consciousness, the GCS of the patients was determined and the cerebrospinal fluid was cultured and sent to the laboratory for the analyses of cell count, diffraction, CSF fluid glucose, CSF fluid protein, LDH, or lactate dehydrogenase, and the level of interleukin 8. Results: The mean of IL-8 protein was 296.17±48.57Pg/ml in patients with aseptic meningitis and 1088.96±526.55Pg/ml in the group of patients with septic meningitis. There was a significant difference between the two groups in terms of the amount of interleukin 8 (p = 0.009). Cutoff was 297.6 Pg/ml for the detection of positive bacterial meningitis with a sensitivity of 92% and the specificity of 83.1% was 297.6 pg/ml. Conclusion: Interleukin 8 has a high sensitivity and specificity in the diagnosis of bacterial meningitis from aseptic meningitis, and along with the measurement of cerebrospinal fluid protein, it can be a good criterion for differentiation of bacterial from aseptic meningitis.https://mj.tbzmed.ac.ir/PDF/mj-42-6-634.pdfinterleukin 8cerebrospinal fluidacute bacterial meningitisaseptic meningitis |
| spellingShingle | Zhinous Bayat-Makoo Puran Karimi Negar Mohtadi Evaluation of IL-8 level in cerebrospinal fluid in acute bacterial meningitis in adults مجله پزشکی دانشگاه علوم پزشکی تبریز interleukin 8 cerebrospinal fluid acute bacterial meningitis aseptic meningitis |
| title | Evaluation of IL-8 level in cerebrospinal fluid in acute bacterial meningitis in adults |
| title_full | Evaluation of IL-8 level in cerebrospinal fluid in acute bacterial meningitis in adults |
| title_fullStr | Evaluation of IL-8 level in cerebrospinal fluid in acute bacterial meningitis in adults |
| title_full_unstemmed | Evaluation of IL-8 level in cerebrospinal fluid in acute bacterial meningitis in adults |
| title_short | Evaluation of IL-8 level in cerebrospinal fluid in acute bacterial meningitis in adults |
| title_sort | evaluation of il 8 level in cerebrospinal fluid in acute bacterial meningitis in adults |
| topic | interleukin 8 cerebrospinal fluid acute bacterial meningitis aseptic meningitis |
| url | https://mj.tbzmed.ac.ir/PDF/mj-42-6-634.pdf |
| work_keys_str_mv | AT zhinousbayatmakoo evaluationofil8levelincerebrospinalfluidinacutebacterialmeningitisinadults AT purankarimi evaluationofil8levelincerebrospinalfluidinacutebacterialmeningitisinadults AT negarmohtadi evaluationofil8levelincerebrospinalfluidinacutebacterialmeningitisinadults |