One severe case of congenital toxoplasmosis in China with good response to azithromycin
Abstract Background Most infants infected with Toxoplasma gondii are completely asymptomatic at birth, yet they may develop ocular and neurological sequelae in the first few months of life. Cases of congenital toxoplasmosis with severe jaundice early after birth combined with pancytopenia and spleno...
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-021-06619-1 |
| _version_ | 1818576742837649408 |
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| author | Jiao Li Jing Zhao Xiaoyan Yang Yang Wen Liang Huang Dan Ma Jing Shi |
| author_facet | Jiao Li Jing Zhao Xiaoyan Yang Yang Wen Liang Huang Dan Ma Jing Shi |
| author_sort | Jiao Li |
| collection | DOAJ |
| description | Abstract Background Most infants infected with Toxoplasma gondii are completely asymptomatic at birth, yet they may develop ocular and neurological sequelae in the first few months of life. Cases of congenital toxoplasmosis with severe jaundice early after birth combined with pancytopenia and splenomegaly are extremely rare. Here, we report on a rare case of congenital toxoplasmosis presenting with severe jaundice and hemolysis early after birth combined with pancytopenia and splenomegaly. Case presentation A male preterm infant with severe jaundice and splenomegaly was admitted to our department. Laboratory examinations revealed severe hyperbilirubinemia, increased reticulocytes, and pancytopenia. After comprehensive analysis and examination, the final diagnosis was congenital toxoplasmosis, and the infant was treated with azithromycin and subsequently trimethoprim-sulfamethoxazole. Regular follow-up revealed congenital toxoplasmosis in both eyes, which was surgically treated, while neurofunctional assessment results were unremarkable. In this case of congenital toxoplasmosis combined with severe jaundice, we treated the infant with two courses of azithromycin, followed by trimethoprim-sulfamethoxazole after the jaundice resolved. Clinical follow-up indicated that this treatment was effective with few side effects; thus, this report may serve as a valuable clinical reference. Conclusions Timely diagnosis and adequate treatment are closely associated with congenital toxoplasmosis-related prognosis. Infants with congenital toxoplasmosis require long-term follow-up, focusing on nervous system development and ophthalmology. |
| first_indexed | 2024-12-16T06:18:52Z |
| format | Article |
| id | doaj.art-26aa80f0911b4cc79f088e51f889ff23 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-16T06:18:52Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-26aa80f0911b4cc79f088e51f889ff232022-12-21T22:41:12ZengBMCBMC Infectious Diseases1471-23342021-09-0121111010.1186/s12879-021-06619-1One severe case of congenital toxoplasmosis in China with good response to azithromycinJiao Li0Jing Zhao1Xiaoyan Yang2Yang Wen3Liang Huang4Dan Ma5Jing Shi6Department of Pediatrics, West China Second University Hospital, Sichuan UniversityDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityDepartment of Pharmacy/Evidence-based Pharmacy Center, West China Second University Hospital of Sichuan UniversityDepartment of Rehabilitation Medicine, West China Second University Hospital of Sichuan UniversityDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityAbstract Background Most infants infected with Toxoplasma gondii are completely asymptomatic at birth, yet they may develop ocular and neurological sequelae in the first few months of life. Cases of congenital toxoplasmosis with severe jaundice early after birth combined with pancytopenia and splenomegaly are extremely rare. Here, we report on a rare case of congenital toxoplasmosis presenting with severe jaundice and hemolysis early after birth combined with pancytopenia and splenomegaly. Case presentation A male preterm infant with severe jaundice and splenomegaly was admitted to our department. Laboratory examinations revealed severe hyperbilirubinemia, increased reticulocytes, and pancytopenia. After comprehensive analysis and examination, the final diagnosis was congenital toxoplasmosis, and the infant was treated with azithromycin and subsequently trimethoprim-sulfamethoxazole. Regular follow-up revealed congenital toxoplasmosis in both eyes, which was surgically treated, while neurofunctional assessment results were unremarkable. In this case of congenital toxoplasmosis combined with severe jaundice, we treated the infant with two courses of azithromycin, followed by trimethoprim-sulfamethoxazole after the jaundice resolved. Clinical follow-up indicated that this treatment was effective with few side effects; thus, this report may serve as a valuable clinical reference. Conclusions Timely diagnosis and adequate treatment are closely associated with congenital toxoplasmosis-related prognosis. Infants with congenital toxoplasmosis require long-term follow-up, focusing on nervous system development and ophthalmology.https://doi.org/10.1186/s12879-021-06619-1Congenital toxoplasmosisJaundicePancytopeniaSplenomegalyCase report |
| spellingShingle | Jiao Li Jing Zhao Xiaoyan Yang Yang Wen Liang Huang Dan Ma Jing Shi One severe case of congenital toxoplasmosis in China with good response to azithromycin BMC Infectious Diseases Congenital toxoplasmosis Jaundice Pancytopenia Splenomegaly Case report |
| title | One severe case of congenital toxoplasmosis in China with good response to azithromycin |
| title_full | One severe case of congenital toxoplasmosis in China with good response to azithromycin |
| title_fullStr | One severe case of congenital toxoplasmosis in China with good response to azithromycin |
| title_full_unstemmed | One severe case of congenital toxoplasmosis in China with good response to azithromycin |
| title_short | One severe case of congenital toxoplasmosis in China with good response to azithromycin |
| title_sort | one severe case of congenital toxoplasmosis in china with good response to azithromycin |
| topic | Congenital toxoplasmosis Jaundice Pancytopenia Splenomegaly Case report |
| url | https://doi.org/10.1186/s12879-021-06619-1 |
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