Aggregation of rhodopsin mutants in mouse models of autosomal dominant retinitis pigmentosa

Aggregation of rhodopsin mutants in mouse models of autosomal dominant retinitis pigmentosa

Abstract Mutations in rhodopsin can cause it to misfold and lead to retinal degeneration. A distinguishing feature of these mutants in vitro is that they mislocalize and aggregate. It is unclear whether or not these features contribute to retinal degeneration observed in vivo. The effect of P23H and...

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Bibliographic Details
Main Authors:	Sreelakshmi Vasudevan, Subhadip Senapati, Maryanne Pendergast, Paul S.–H. Park
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-024-45748-4

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