Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis
Nanomedicine is important in cancer therapy, but loading, drug release, and therapeutic effectiveness issues limit the translation to the clinic. Here, authors report a full-API nanodrug with an ideal API content and pH-responsive release for continuous spatiotemporal cancer therapy based on PpIX-he...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37315-0 |
| _version_ | 1797859869692264448 |
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| author | Fang Fang Sa Wang Yueyue Song Meng Sun Wen-Cheng Chen Dongxu Zhao Jinfeng Zhang |
| author_facet | Fang Fang Sa Wang Yueyue Song Meng Sun Wen-Cheng Chen Dongxu Zhao Jinfeng Zhang |
| author_sort | Fang Fang |
| collection | DOAJ |
| description | Nanomedicine is important in cancer therapy, but loading, drug release, and therapeutic effectiveness issues limit the translation to the clinic. Here, authors report a full-API nanodrug with an ideal API content and pH-responsive release for continuous spatiotemporal cancer therapy based on PpIX-heme-CO/Fe2+/BV-BR metabolic pathway. |
| first_indexed | 2024-04-09T21:36:33Z |
| format | Article |
| id | doaj.art-26aca79b76574f5ebbba8892ac578b0b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T21:36:33Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-26aca79b76574f5ebbba8892ac578b0b2023-03-26T11:14:34ZengNature PortfolioNature Communications2041-17232023-03-0114111410.1038/s41467-023-37315-0Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous BiosynthesisFang Fang0Sa Wang1Yueyue Song2Meng Sun3Wen-Cheng Chen4Dongxu Zhao5Jinfeng Zhang6Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of TechnologyKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of TechnologyKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of TechnologyKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of TechnologySchool of Chemical Engineering and Light Industry, Guangdong University of TechnologyKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of TechnologyKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of TechnologyNanomedicine is important in cancer therapy, but loading, drug release, and therapeutic effectiveness issues limit the translation to the clinic. Here, authors report a full-API nanodrug with an ideal API content and pH-responsive release for continuous spatiotemporal cancer therapy based on PpIX-heme-CO/Fe2+/BV-BR metabolic pathway.https://doi.org/10.1038/s41467-023-37315-0 |
| spellingShingle | Fang Fang Sa Wang Yueyue Song Meng Sun Wen-Cheng Chen Dongxu Zhao Jinfeng Zhang Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis Nature Communications |
| title | Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis |
| title_full | Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis |
| title_fullStr | Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis |
| title_full_unstemmed | Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis |
| title_short | Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis |
| title_sort | continuous spatiotemporal therapy of a full api nanodrug via multi step tandem endogenous biosynthesis |
| url | https://doi.org/10.1038/s41467-023-37315-0 |
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